发明申请
- 专利标题： Molecular Signatures for Distinguishing Liver Transplant Rejections or Injuries
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申请号： US17401643申请日： 2021-08-13
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公开(公告)号： US20220205042A1公开(公告)日： 2022-06-30
- 发明人: Daniel R. Salomon , Josh Levitsky , Sunil Kurian , Michael Abecassis
- 申请人： The Scripps Research Institute , Northwestern University
- 申请人地址： US CA La Jolla; US IL Evanston
- 专利权人： The Scripps Research Institute,Northwestern University
- 当前专利权人： The Scripps Research Institute,Northwestern University
- 当前专利权人地址： US CA La Jolla; US IL Evanston
- 主分类号： C12Q1/6883
- IPC分类号： C12Q1/6883 ; G01N33/50 ; G16H50/30 ; G16H20/40 ; G16H20/10 ; G16H20/17 ; G16H50/70 ; G16H50/20 ; G16H40/63
摘要：
By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.
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