Guided restoration is used to restore video data degraded from a video frame. The video frame is divided into restoration units (RUs) which each correspond to one or more blocks of the video frame. Restoration schemes are selected for each RU. The restoration schemes may indicate to use one of a plurality of neural networks trained for the guided restoration. Alternatively, the restoration schemes may indicate to use a neural network and a filter-based restoration tool. The video frame is then restored by processing each RU according to the respective selected restoration scheme. During encoding, the restored video frame is encoded to an output bitstream, and the use of the selected restoration schemes may be signaled within the output bitstream. During decoding, the restored video frame is output to an output video stream.