- 专利标题： METHOD OF TREATMENT
-
申请号： US17703111申请日： 2022-03-24
-
公开(公告)号： US20220213143A1公开(公告)日： 2022-07-07
- 发明人: Stavros SELEMIDIS , Doug A. BROOKS , John O'LEARY
- 申请人： ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTH AUSTRALIA , THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF , MONASH UNIVERSITY
- 申请人地址： AU Melbourne; AU South Australia; IE Dublin 2; AU Clayton
- 专利权人： ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY,UNIVERSITY OF SOUTH AUSTRALIA,THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF,MONASH UNIVERSITY
- 当前专利权人： ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY,UNIVERSITY OF SOUTH AUSTRALIA,THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF,MONASH UNIVERSITY
- 当前专利权人地址： AU Melbourne; AU South Australia; IE Dublin 2; AU Clayton
- 优先权： AU2017902545 20170630
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; A61P37/00 ; A61P31/00 ; A61P29/00 ; A61P35/00 ; C07K14/705
摘要：
The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.
信息查询
