-
公开(公告)号:US20250122631A1
公开(公告)日:2025-04-17
申请号:US18567599
申请日:2022-05-25
Applicant: MONASH UNIVERSITY
Inventor: Douglas R. MACFARLANE , Alexandr Nikolaevich SIMONOV , Hoang-Long DU
Abstract: The invention provides a method of reducing dinitrogen to produce ammonia, the method comprising: contacting a cathode of an electrochemical cell with an electrolyte comprising: (i) a metal cation selected from the group consisting of lithium, magnesium, calcium, strontium, barium, zinc, aluminium, vanadium and combinations thereof, wherein the metal cation is present at a concentration of greater than 0.5 mol/L in the electrolyte, (ii) one or more anions comprising at least one negative ion selected from the group consisting of fluorinated sulfonyl imides, fluorinated sulfonyl methides and combinations thereof, (iii) a proton carrier; and (iv) optionally, at least one phosphonium cation, wherein the combined amount of the metal cation and the optional at least one phosphonium cation is greater than 1 mol/L in the electrolyte; supplying dinitrogen to the electrochemical cell for cathodic reduction; and applying a potential at the cathode sufficient to reduce the dinitrogen, thereby producing ammonia.
-
公开(公告)号:US20250108018A1
公开(公告)日:2025-04-03
申请号:US18930615
申请日:2024-10-29
Applicant: Monash University
Inventor: Johanna Elisabeth FRASER , David Andrew JANS , Kylie Michelle WAGSTAFF
IPC: A61K31/167 , A61K31/203
Abstract: This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, West Nile virus or Japanese encephalitis virus or infections caused by Chikungunya virus (CHIKV). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with CHIKV, or to those who are at risk of becoming infected with a flavivirus or becoming infected with CHIKV.
-
公开(公告)号:US20250034222A1
公开(公告)日:2025-01-30
申请号:US18717170
申请日:2022-12-07
Applicant: Monash University , HUdson Institute of Medical Research
Abstract: This invention relates to polypeptides, including variants of interleukin-38 (IL-38), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric polypeptide comprising an amino acid sequence of an IL-38 monomer, the amino acid sequence having a mutation or modification for preventing the peptide from forming a homodimer and favouring the formation of a stable monomer.
-
公开(公告)号:US20240382588A1
公开(公告)日:2024-11-21
申请号:US18693109
申请日:2022-09-21
Applicant: MONASH UNIVERSITY
Inventor: Joshua Daniel OOI , Peter James EGGENHUIZEN , Eric MORAND
IPC: A61K39/00 , A61P37/06 , C07K14/725 , C12N5/0783
Abstract: The present invention relates to methods and compositions for treating autoimmune or inflammatory disease characterised by an aberrant or inappropriate immune response to one or more of Ro60 protein; MPO protein; and Smith protein.
-
公开(公告)号:US20240358652A1
公开(公告)日:2024-10-31
申请号:US18291808
申请日:2022-08-17
Applicant: Monash University
Inventor: Hareth Basim Ali AL-WASSITI , Colin William POUTON , Kha Tu Joan HO
IPC: A61K9/51 , A61K31/713 , A61K39/00 , A61K48/00 , A61P37/08
CPC classification number: A61K9/5146 , A61K9/5123 , A61K31/713 , A61K39/0005 , A61K48/0041 , A61P37/08 , A61K2039/53 , A61K2039/55555 , A61K2039/572
Abstract: The present invention is directed to lipid nanoparticles, formulations containing lipid nanoparticles and methods of treating diseases or conditions with said lipid nanoparticles and formulations thereof. A lipid nanoparticle comprising (a) an active agent; (b) a cationic and/or ionisable lipid comprising from about 40 mol % to about 60 mol % of the total lipid present in the nanoparticle; (c) a phospholipid comprising from about 5 mol % to about 20 mol % of the total lipid present in the nanoparticle; (d) a structural lipid comprising from about 30 mol % to about 50 mol % of the total lipid present in the nanoparticle; (e) a PEGylated lipid comprising from about 0.05 mol % to less than 0.5 mol % of the total lipid present in the nanoparticle.
-
公开(公告)号:US20240141360A1
公开(公告)日:2024-05-02
申请号:US18310289
申请日:2023-05-01
Applicant: MONASH UNIVERSITY , MURDOCH UNIVERSITY
Inventor: Stephen WILTON , Merlin Christopher THOMAS , Carlos ROSADO , Raelene Jane PICKERING
IPC: C12N15/113
CPC classification number: C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3233 , C12N2310/3513 , C12N2320/30 , C12N2320/33
Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.
-
公开(公告)号:US11954823B2
公开(公告)日:2024-04-09
申请号:US17055522
申请日:2019-05-14
Applicant: MONASH UNIVERSITY
Inventor: Kamlesh Pawar , Zhaolin Chen , Nadim Joni Shah , Gary Francis Egan
IPC: G06T3/40 , G01R33/48 , G01R33/56 , G06T3/4046 , G06T3/4076
CPC classification number: G06T3/4076 , G01R33/4818 , G01R33/5608 , G06T3/4046
Abstract: A method and system for reconstructing magnetic resonance (MR) images, the method including the steps of: receiving an under-sampled MR image, the under-sampled MR image being transformed from under-sampled k-spaced data; classifying intensity of each pixel in the under-sampled MR image to one of a plurality of predetermined quantized values of intensity by using a neural network; and generating a reconstructed MR image based on the classified quantized value of the intensity for each pixel in the under-sampled MR image.
-
公开(公告)号:USD1019932S1
公开(公告)日:2024-03-26
申请号:US29765322
申请日:2021-01-07
Applicant: Monash University
Designer: Richard Morfuni , Daphne Flynn , Rowan Page , Mark C. Armstrong , Tuncay Alan , Jason Brenker
Abstract: FIG. 1 is a top perspective view of an inhaler showing our new design;
FIG. 2 is a bottom perspective view thereof;
FIG. 3 is a top plan view thereof;
FIG. 4 is a front elevational view thereof;
FIG. 5 is a rear elevational view thereof;
FIG. 6 is a bottom plan view thereof; and,
FIG. 7 is a left side elevational view thereof, the right side elevational view being a mirror image thereof.
The broken lines in the figures depict portions of the inhaler which form no part of the claimed design.
The black areas in the figures depict portions of the inhaler having a contrasting surface appearance, such as contrasting color, including black.-
公开(公告)号:US11878165B2
公开(公告)日:2024-01-23
申请号:US17346971
申请日:2021-06-14
Applicant: MONASH UNIVERSITY
Inventor: Paul B Fitzgerald , Caley M. Sullivan , Richard H. Thomson
CPC classification number: A61N1/36031 , A61B5/369 , A61B5/375 , A61B5/4064 , A61B5/4836 , A61B5/7203 , A61N1/36025 , A61B5/0042 , A61B5/318 , A61B5/389 , A61B5/6814 , A61N1/0476
Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.
-
10.
公开(公告)号:US20230282944A1
公开(公告)日:2023-09-07
申请号:US18006404
申请日:2021-07-23
Applicant: MONASH UNIVERSITY
Inventor: Petar JOVANOVIC , Mahdokht SHAIBANI , Mainak MAJUMDER
IPC: H01M50/497 , H01M50/403 , H01M50/417 , B82Y30/00 , B82Y40/00 , H01M10/052
CPC classification number: H01M50/497 , H01M50/403 , H01M50/417 , B82Y30/00 , B82Y40/00 , H01M10/052 , H01M2300/0082 , H01M2300/0094
Abstract: A method of making a polyelectrolyte complex membrane separator for a Lithium-Sulfur battery to support lean electrolyte operation, comprising the steps of: forming polyelectrolyte complex nanoparticles by the addition of polyethylenimine (PEI) to tannic acid (TA); adding bovine serum albumin (BSA); purifying the nanoparticles; re-dispersing the nanoparticles in water to form a nanoparticle suspension; and dipcoating a polyolefin membrane in the nanoparticle suspension.
-
-
-
-
-
-
-
-
-