发明申请
- 专利标题: CANCER VACCINE
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申请号: US17264469申请日: 2020-10-19
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公开(公告)号: US20220233666A1公开(公告)日: 2022-07-28
- 发明人: Natalia SAVELYEVA , Gareth THOMAS , Christian OTTENSMEIER , Chuan WANG , Sok Ching CHEONG , Kue Peng LIM
- 申请人: University of Southampton , Cancer Research Malaysia
- 申请人地址: GB Southampton, Hampshire; MY Subang Jaya, Selangor
- 专利权人: University of Southampton,Cancer Research Malaysia
- 当前专利权人: University of Southampton,Cancer Research Malaysia
- 当前专利权人地址: GB Southampton, Hampshire; MY Subang Jaya, Selangor
- 优先权: GB1915163.8 20191018
- 国际申请: PCT/GB2020/052631 WO 20201019
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61P35/00
摘要:
The present invention relates to nucleic acid vaccines which encode at least a MAGED4B protein, for use in the treatment of cancer in particular. Synergistic combinations with other anti-cancer agents are described, particularly immune checkpoint inhibitors. The cancer vaccine may further comprise an immunologically active fragment to enhance the immune response, and an additional cancer antigen, such as FJX1. Particular combination therapies of interest include immunotherapies, radiotherapy, targeted therapies and chemotherapies.