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公开(公告)号：US12211241B2
公开(公告)日：2025-01-28
申请号：US17618607
申请日：2020-06-12
Inventor： Nikolay Ivanovich Zheludev , Guanghui Yuan , Nikitas Papasimakis , Vassily Savinov
IPC: G06V10/145 , G06V10/147 , G06V10/774 , G06V10/82 , G06V20/66 , G06V10/10
Abstract: A method of imaging comprises: generating a superoscillatory field from coherent electromagnetic radiation; placing an object in the superoscillatory field; detecting one or more intensity distributions of the superoscillatory field scattered by the object; and determining at least one characteristic of the object from the one or more intensity distributions.
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公开(公告)号：US12196615B2
公开(公告)日：2025-01-14
申请号：US17800093
申请日：2021-02-16
Applicant: University of Southampton
Inventor： Sumeet Mahajan , Niall Hanrahan , Konstaninos Bourdakos , Simon Lane
Abstract: A method for obtaining chemical and/or material specific information of a sample based on scattered light. The method comprises receiving detection data comprising at least two images. Each image is indicative of the intensity of scattered light i) for incident light of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state. The scattered light comprises an elastic scattering component that is due to Rayleigh scattering of the incident light in at least a portion of the sample. Alternatively, each image is indicative of the intensity of scattered light i) of a different wavelength, or ii) for incident light of a different polarization state, or iii) of a different polarization state, wherein the scattered light comprises an inelastic scattering component that is due to Raman scattering of the incident light in at least a portion of the sample. The method further comprises determining the chemical and/or material specific information of the sample based on the change in intensity of the elastic scattering component in dependence on the change in wavelength and/or the change in polarization state of the incident and/or scattered light.
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公开(公告)号：US20240413609A1
公开(公告)日：2024-12-12
申请号：US18697112
申请日：2022-09-28
Applicant: University of Southampton
Inventor： Peter George Robin SMITH , Rex Hugh Seton BANNERMAN , Devin Hugh SMITH
Abstract: An optical source comprises: a pump source operable to generate laser light at a first wavelength; a single mode optical fibre arranged to receive laser light at the first wavelength from the pump source, the optical fibre being fabricated from material having a Raman gain profile for stimulated Raman scattering of light at the first wavelength, and a Brillouin gain profile for stimulated Brillouin scattering of light at the second wavelength to a third wavelength longer than the second wavelength; and a superstructured fibre Bragg grating formed in the optical fibre, the grating comprising: a periodic refractive index profile along a core of the optical fibre, giving transmission of the first wavelength to allow received laser light at the first wavelength to enter the superstructured fibre Bragg grating, reflection of the second wavelength at a first level, and reflection of the third wavelength at a second level lower than the first level; and a phase shift at an intermediate location along a length of the grating; wherein the series of pulses at the third wavelength comprise a pulsed output of the optical source.
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公开(公告)号：US12040585B2
公开(公告)日：2024-07-16
申请号：US17181472
申请日：2021-02-22
Applicant: University of Southampton
Inventor： Masaaki Sakakura , Yanhao Yu , Peter Kazansky , Lei Wang
IPC: G11B7/0037 , B23K26/0622 , B23K26/08 , B23K26/082 , G01N21/95 , G02B5/30 , G02B26/08 , G02B27/09 , G02F1/33 , G11B7/127 , H01S3/00 , B82Y10/00
CPC classification number: H01S3/0057 , B23K26/0624 , B23K26/08 , B23K26/082 , B23K26/083 , G02B5/3083 , G02B26/0808 , G02B27/0944 , G02F1/33 , B82Y10/00
Abstract: A method of delivering optical pulses to a substrate comprises directing a focused beam from a source of optical pulses along a propagation direction onto a substrate; moving the substrate relative to the beam in a plane substantially orthogonal to the propagation direction and continuously along a first direction that includes spaced apart row locations on the substrate, and delivering a plurality of optical pulses from source as the beam reaches each row location; and between delivering the optical pulses at consecutive row locations, moving the beam relative to the substrate in one or more successive discrete movements along a second direction in the plane orthogonal to the first direction, to direct the beam to one or more spaced apart column locations on the substrate, and delivering a plurality of optical pulses from the source at each column location.
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公开(公告)号：US20240092912A1
公开(公告)日：2024-03-21
申请号：US18281530
申请日：2022-03-09
Applicant: BIOINVENT INTERNATIONAL AB , UNIVERSITY OF SOUTHAMPTON
Inventor： Björn FRENDÉUS , Linda MÅRTENSSON , Ingrid TEIGE , Mark CRAGG , Robert OLDHAM , Stephen BEERS , Ali ROGHANIAN
CPC classification number: C07K16/283 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/507
Abstract: The present invention generally relates to antibody combinations and uses thereof.
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Patent Agency Ranking
公开(公告)号：US11815515B2
公开(公告)日：2023-11-14
申请号：US16962357
申请日：2019-01-14
Inventor： Jerome Feige , Keith Malcolm Godfrey , Neerja Karnani , Eugenia Migliavacca
IPC: G01N33/68 , A23L33/105 , A23L33/15
CPC classification number: G01N33/6887 , A23L33/105 , A23L33/15 , A23V2002/00 , G01N2800/10 , G01N2800/50 , G01N2800/52
Abstract: The present invention relates in general to the field of muscle disease. In particular, the invention relates to a method for determining if a subject has sarcopenia or has an increased risk of developing sarcopenia. A method of predicting the responsiveness of said subject to nutritional intervention is also provided.
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公开(公告)号：US11802993B2
公开(公告)日：2023-10-31
申请号：US16970242
申请日：2019-02-13
Applicant: University of Southampton
Inventor： Rokas Drevinskas , Peter Kazansky , Ausra Cerkauskaite
CPC classification number: G02B1/002 , G02B5/3083 , G02B27/286
Abstract: An optical element for modifying an incident laser beam propagated through the optical element from an input face to an output face via a geometric phase birefringent effect, the optical element comprising: a substrate of a transparent amorphous material with an input face and an opposite output face; and a structural modification in a volume of the substrate between the input face and output face comprising a plurality of randomly positioned nanostructures; wherein each nanostructure has a oblate spheroidal shape with an elliptical cross section in a plane parallel to the input face, the elliptical cross-section having a minor axis substantially not larger than 30 nm and a major axis greater than the minor axis, and each nanostructure having a length in a direction perpendicular to the input face which is substantially not larger than 100 nm.
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公开(公告)号：US11644469B2
公开(公告)日：2023-05-09
申请号：US17194522
申请日：2021-03-08
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Ali Tavassoli
CPC classification number: G01N33/6845 , A61K38/08 , A61K38/18 , A61P35/00 , C07K7/02 , C07K7/06 , C07K14/4702 , G01N2500/02
Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1α with HIF-1β and HIF-2α with HIF-1β and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO: 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1α with HIF-1β and HIF-2α with HIF-1β and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1α or HIF-1β and/or HIF-2α or HIF-1β.
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公开(公告)号：US20230070339A1
公开(公告)日：2023-03-09
申请号：US17799240
申请日：2021-02-12
Applicant: University of Southampton , BIOINVENT INTERNATIONAL AB
Inventor： Björn FRENDÉUS , All Roghanian , Mark GRAGG
Abstract: Described are anti-LILRB3 antibody molecules, such as agonistic anti-LILRB3 antibody molecules for use in treatment of graft rejection or autoimmunity via reprograming of human myeloid cells. Described are also specific anti-LILRB3 antibody molecules and use of such antibody molecules in medicine, for example in treatment of graft rejection, autoimmune disorders or inflammatory disorders.
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10.发明申请公开(公告)号：US20230009601A1
公开(公告)日：2023-01-12
申请号：US17902274
申请日：2022-09-02
Applicant: University of Southampton
Inventor： Austin Taranta , Eirc Numkam Fokoua , Francesco Poletti , David Neil Payne
IPC: G02B6/02
Abstract: An interferometric optical fibre sensor comprises optical fibre defining an optical circuit configured to propagate a first optical wave via an environment in which the optical fibre can be exposed to a stimulus that modifies the first optical wave, and a second optical wave, and to combine the first optical wave and the second optical wave to create an interference signal containing information about the stimulus, wherein optical fibre propagating either or both of the first optical wave and the second optical wave comprises hollow core optical fibre configured to propagate the optical wave or waves by an antiresonant optical guidance effect.
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