Invention Application
- Patent Title: De Novo Design of Potent and Selective Interleukin Mimetics
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Application No.: US17698553Application Date: 2022-03-18
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Publication No.: US20220235110A1Publication Date: 2022-07-28
- Inventor: Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl WALKEY
- Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Applicant Address: US WA Seattle; US CA Stanford
- Assignee: UNIVERSITY OF WASHINGTON,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee: UNIVERSITY OF WASHINGTON,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee Address: US WA Seattle; US CA Stanford
- Main IPC: C07K14/55
- IPC: C07K14/55 ; C07K14/54 ; A61K47/62 ; A61K47/60
Abstract:
De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
Public/Granted literature
- US12240880B2 De novo design of potent and selective interleukin mimetics Public/Granted day:2025-03-04
Information query
