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公开(公告)号:US20250152504A1
公开(公告)日:2025-05-15
申请号:US18941995
申请日:2024-11-08
Inventor: Hannah VanBenschoten , Kim Woodrow , Ian Suydam , Jeffrey Jensen , Bob Katz
IPC: A61K9/00 , A61K31/439 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/65 , A61K47/34
Abstract: An intrauterine system configured to be retained in a uterus of a patient, the intrauterine system including a delivery system configured to deliver one or more active compounds, where the one or more active compounds have non-systemic extrauterine biological targets. Further, a method of using the intrauterine system, including retaining the intrauterine system in a uterus, and delivering the one or more active compounds to non-systemic extrauterine biological targets in the lower female reproductive tract (LFRT) or the rectum.
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公开(公告)号:US20250135016A1
公开(公告)日:2025-05-01
申请号:US18935315
申请日:2024-11-01
Applicant: University of Washington
Inventor: Cole DeForest , Barry Badeau
Abstract: The present disclosure features, inter alia, a cyclic multifunctional linker, including at least two cleavable moieties; at least two connecting chains connected to the at least two cleavable moieties to provide a cyclic structure; and at least two linking groups, each linking group being bonded at one end to a connecting chain and being located between two cleavable moieties, and each linking group having a second end configured to bond to crosslinkable moieties. In the cyclic multifunctional linker, each connecting chain has at least two ends, and at least two of the connecting chains are each connected at each end to a cleavable moiety.
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公开(公告)号:US12285859B2
公开(公告)日:2025-04-29
申请号:US17686350
申请日:2022-03-03
Applicant: The Boeing Company , University of Washington
Inventor: Jerry D. Chungbin , Shuonan Dong , John W. Fuller , Samuel F. Pedigo , Santosh Devasia , Benjamin Yat-Chun Wong , Kyle William Schultz , Wade Marquette , Lucky Singh , Derek Keith Loy , Joseph L. Garbini
Abstract: There is provided a mechanical avatar assembly for use in a confined space in a structure. The mechanical avatar assembly includes a rail assembly for attachment to an access opening to the confined space. The rail assembly includes two or more rail segments coupled together to form an elongated base having a rail and a gear rack extending along a length of the elongated base. The rail assembly further includes a carriage portion coupled to the rail, and movable relative to the rail, and a drive assembly coupled to the carriage portion and to the gear rack, to move the carriage portion along the rail. The mechanical avatar assembly further includes an articulating avatar arm coupled to, and movable via, the carriage portion. The mechanical avatar assembly further includes an image capturing device.
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公开(公告)号:US12285636B2
公开(公告)日:2025-04-29
申请号:US17881026
申请日:2022-08-04
Applicant: University of Washington
Inventor: Michael R. Bailey , Mohamed Abdalla Ghanem , Adam D. Maxwell
Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.
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公开(公告)号:US12285482B2
公开(公告)日:2025-04-29
申请号:US17810480
申请日:2022-07-01
Applicant: University of Washington , ABACUS BIOSCIENCE, INC.
Inventor: Edward A. Clark , Che-Leung Law , Deborah Fuller , Michael Gale
Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.
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公开(公告)号:US20250130444A1
公开(公告)日:2025-04-24
申请号:US18788492
申请日:2024-07-30
Applicant: UNIVERSITY OF WASHINGTON
Inventor: Virat Tara , Anna-Wirth Singh , Abhi Saxena , Johannes Emanuel Fröch , Matthew S. Reynolds , Rui Chen , Arka Majumdar
Abstract: Spatial light modulators and associated methods are described. In one embodiment, a spatial light modulator includes a photonic integrated circuit configured for emitting a plurality of light beams as a first waveform by a plurality of pixels. The light beams are individually controllable. The spatial light modulator also includes a meta-optic having a plurality of nanostructures configured for receiving the first waveform and aggregating the plurality of light beams as a second waveform at a surface of the meta-optic. The spatial light modulator also includes an aperture array configured for converting the second waveform into a third waveform, where the third waveform is smaller than the second waveform.
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公开(公告)号:US20250130230A1
公开(公告)日:2025-04-24
申请号:US18691615
申请日:2022-09-27
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , UNIVERSITY OF WASHINGTON
Inventor: Chao Wang , Liangcai Gu , Xiahui Chen , Shoukai Kang , MD Ashif Ikbal , Zhi Zhao
IPC: G01N33/569 , G01N33/543 , G01N33/553
Abstract: Provided herein are methods of detecting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) and/or other plasmonic metal nanoparticles (MNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first and second epitopes of SARS-CoV-2 proteins, such as receptor-binding domain (RBDs) under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first and second epitopes of the SARS-CoV-2 proteins in the sample to produce bound SARS-CoV-2 proteins. The methods also include detecting the SARS-CoV-2 proteins when aggregations of the bound SARS-CoV-2 proteins form with one another. Related compositions, reaction mixtures, devices, kits, and systems are also provided.
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公开(公告)号:US12280376B2
公开(公告)日:2025-04-22
申请号:US17424397
申请日:2020-02-04
Applicant: University of Washington
Inventor: Daniel Chiu , Li Wu , Yuling Qin
IPC: B01L3/00
Abstract: Devices and systems for droplet generation and methods for generating droplets are described. In an embodiment, the devices and systems include a capillary configured to eject a droplet, such as in response to a voltage applied to an end of the capillary. In an embodiment, the devices and systems include a moveable stage configured to carry a multi-well plate and move the stage relative to the capillary such that the ejected droplet is selectively received by a well of the multi-well plate carried by the moveable stage.
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公开(公告)号:US20250122318A1
公开(公告)日:2025-04-17
申请号:US18990014
申请日:2024-12-20
Applicant: University of Washington
Inventor: Delwin Elder , Huajun Xu , Bruce H. Robinson , Larry R. Dalton
IPC: C08F220/14 , C08F220/16 , C08F220/30 , C08J3/24 , C08J5/18 , G02F1/361
Abstract: Crosslinked films having electro-optic activity, compositions and compounds for making the films, methods for making the films, and devices that include the films are disclosed.
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公开(公告)号:US20250115528A1
公开(公告)日:2025-04-10
申请号:US18725318
申请日:2023-01-05
Applicant: University of Washington
Inventor: Mari-Karoliina Henriikka Winkler , Korena Mafune
Abstract: Embodiments of the present disclosure provide compositions and methods for increasing nutrient uptake by plants and for effecting soil remediation. Embodiments of the composition and methods comprise a hydrogel bead, a microbial consortia, and a fungi, and can additionally comprise an excipient for administration of the hydrogel bead comprising the microbial consortia and the fungi, one or more seed, water, one or more nutrients, and combinations thereof. Such composition and methods have broad application to reduce fertilizer requirements and use, and to increase plant nutrient access and uptake. The composition and methods have additional application to remediate contaminated mediums such as soil contaminated with chemicals, petroleum, and explosives.
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