A cable-operated drive mechanism for a powered motor vehicle sliding closure panel and method of construction of the cable-operated drive mechanism is provided. The cable-operated drive mechanism includes a cable drum mechanism having a first cable drum supported for rotation about a first drum axis and a second cable drum supported for rotation about a second drum axis. A first cable winds and unwinds about the first cable drum in response to rotation of the first cable drum in opposite directions and a second cable unwinds and winds about the second cable drum in response to rotation of the second cable drum in opposite directions. A drive member is operably coupled to at least one of the first cable drum and second cable drum to drive the first and second cable drums in unison with one another.