Invention Application
- Patent Title: PEPTIDES AND USE OF SAME IN THE TREATMENT OF DISEASES, DISRODERS OR CONDITIONS ASSOCIATED WITH A MUTANT P53
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Application No.: US17549369Application Date: 2021-12-13
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Publication No.: US20220251159A1Publication Date: 2022-08-11
- Inventor: Varda ROTTER , Moshe OREN , Perry TAL , Shay EIZENBERGER , Avi BEN-SHIMON
- Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD
- Applicant Address: IL Rehovot
- Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD
- Current Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD
- Current Assignee Address: IL Rehovot
- Main IPC: C07K14/47
- IPC: C07K14/47 ; A61P35/00 ; C12N15/09
Abstract:
An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
Information query
