Disclosed dressing embodiments may include a tissue interface and a cover, with the tissue interface shaped anatomically for interaction with a specific anatomical region, such as a foot. Such tissue interface embodiments would typically comprise a manifold and a fluid control layer having a plurality of fluid restrictions, with the manifold disposed in a stacked relationship with the fluid control layer. Some embodiments of the tissue interface might also include a gel layer in a stacked relationship with the fluid control layer, opposite the manifold. For foot dressings, tissue interface embodiments may be shaped with a hindfoot section, an underfoot section, and a forefoot extension section.