- 专利标题： COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)
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申请号： US17618873申请日： 2020-06-12
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公开(公告)号： US20220267269A1公开(公告)日： 2022-08-25
- 发明人: Simeon Bowers , Mark Karbarz , Jiang Zhu , Thomas E. Barta , Jonathan William Bourne , Anjali Pandey
- 申请人： SRX Cardio, LLC
- 申请人地址： US NY Pittsford
- 专利权人： SRX Cardio, LLC
- 当前专利权人： SRX Cardio, LLC
- 当前专利权人地址： US NY Pittsford
- 国际申请： PCT/US2020/037591 WO 20200612
- 主分类号： C07D211/42
- IPC分类号： C07D211/42 ; C07D207/08 ; C07D211/14 ; C07D211/18 ; C07D211/38 ; C07D211/56 ; C07D233/10 ; C07D233/22 ; C07D265/30 ; C07D401/04 ; C07D401/06 ; C07D401/10 ; C07D401/14 ; C07D405/04 ; C07D405/06 ; C07D405/14 ; C07D413/14 ; C07D417/04 ; C07D471/04 ; C07D471/14 ; C07D498/04
摘要：
The present disclosure relates to novel compounds capable of binding to PCSK9, thereby modulating PCSK9 biological activity. Also provided are compositions comprising these compounds, methods of preparing the compounds, and methods for use of the compounds in the treatment of PCSK9-related conditions and diseases.
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