Disclosed is a bioprocess system (1) comprising a flow path (3; 3a, 3) comprising: a plurality of inlets (7); at least one bio-processing device inlet connection (9a) and at least one bioprocessing device outlet connection (9b); a plurality of outlets (11); and flow path parts (5a′, 5b′, 5c′, 5d′, 5e′) of at least some active components (5a, 5b, 5c, 5d, 5e) comprised in the bioprocess system; and active parts (5a″, 5b″, 5c″, 5d″, 5e″) of said active components (5a, 5b, 5c, 5d, 5e). The flow path (3; 3a, 3b) of the bioprocess system is positioned centrally within the bioprocess system (1) and in a vertical orientation, whereby the active parts (5a″, 5b″, 5c″, 5d″, 5e″) are positioned around the flow path (3; 3a, 3b) being accessible from outside the bioprocess system (1) and each in connection with a corresponding flow path part (5a′, 5b′, 5c′, 5d′, 5e′) of an active component (5a, 5b, 5c, 5d, 5e).