Methods and apparatus to mitigate coexistence interference in a wireless network are disclosed. An example apparatus includes a station component interface to receive an expected transmission power from an access point; an index processor to determine a set of preferred resource unit (RU) indexes from a set of available RU indexes for at least one of (A) uplink transmission to the access point based on a comparison of allowable transmission power and the expected transmission power or (B) downlink reception based on a comparison of a noise floor to a noise threshold; and the station component interface to transmit a message including the preferred RU indexes to the access point.