Disclosed are methods for localized treatment of a skin condition including administering a therapeutically effective amount of at least one Janus kinase inhibitor (JAKi) to the subject, utilizing a dosimetry device to transmit varying percentages of the UVB light to an area of the subject's skin; assessing a response of the treated area to the varying percentages of the UVB light transmitted thereto; and determining an optimal dose of UVB light, based on the response of the treated area to the varying percentages of UVB light and to the JAKi; and applying the optimal dose of UVB light to the treatment area.