- 专利标题： COMPOSITIONS INCLUDING IGG FC MUTATIONS AND USES THEREOF
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申请号： US17638139申请日： 2020-08-27
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公开(公告)号： US20220306735A1公开(公告)日： 2022-09-29
- 发明人: Brandon DEKOSKY , Peter D. KWONG , Wei JIN , Young Do KWON , Baoshan ZHANG
- 申请人： University of Kansas , The U.S.A. as rep by the Sec., Dept. of Health and Human SVCS.
- 申请人地址： US KS Lawrence; US MD Bethesda
- 专利权人： University of Kansas,The U.S.A. as rep by the Sec., Dept. of Health and Human SVCS.
- 当前专利权人： University of Kansas,The U.S.A. as rep by the Sec., Dept. of Health and Human SVCS.
- 当前专利权人地址： US KS Lawrence; US MD Bethesda
- 国际申请： PCT/US2020/048253 WO 20200827
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/10
摘要：
The present disclosure relates generally to antibodies and Fc fusion proteins comprising Fc variants, and uses thereof. The Fc variants disclosed herein exhibit elevated affinity towards FcRn at pH 6.0, and/or rapidly disassociate from FcRn at pH 7.4 compared to a parent Fc domain