专利检索 ap:("University of Kansas" OR "The U.S.A. as rep by the Sec., Dept. of Health AND Human SVCS.") AND inv:"Peter D. KWONG" 第 1 页

1.

发明申请
COMPOSITIONS INCLUDING IGG FC MUTATIONS AND USES THEREOF 有权

公开(公告)号：US20220306735A1

公开(公告)日：2022-09-29

申请号：US17638139

申请日：2020-08-27

申请人： University of Kansas , The U.S.A. as rep by the Sec., Dept. of Health and Human SVCS.

发明人： Brandon DEKOSKY , Peter D. KWONG , Wei JIN , Young Do KWON , Baoshan ZHANG

IPC分类号： C07K16/28 , C07K16/10

摘要： The present disclosure relates generally to antibodies and Fc fusion proteins comprising Fc variants, and uses thereof. The Fc variants disclosed herein exhibit elevated affinity towards FcRn at pH 6.0, and/or rapidly disassociate from FcRn at pH 7.4 compared to a parent Fc domain