Invention Application
- Patent Title: AUTOMATED SEMI-PREPARATIVE GRADIENT RECYCLING LIQUID CHROMATOGRAPHY
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Application No.: US17699775Application Date: 2022-03-21
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Publication No.: US20220308020A1Publication Date: 2022-09-29
- Inventor: Fabrice Gritti
- Applicant: Waters Technologies Corporation
- Applicant Address: US MA Milford
- Assignee: Waters Technologies Corporation
- Current Assignee: Waters Technologies Corporation
- Current Assignee Address: US MA Milford
- Main IPC: G01N30/46
- IPC: G01N30/46 ; G01N30/82

Abstract:
The disclosure relates to a gradient twin column recycling chromatography method that is used to separate a mixture containing closely eluting compounds. In one embodiment, a sample includes a primary organic compound and one or more impurities that closely elute with the primary organic compound. A gradient mobile phase is initially used to remove unwanted early eluting and late eluting impurities from the sample. After the gradient removal of some of the impurities is complete, the remaining mixture of the primary organic compound and the closely eluting impurities are separated using recycle chromatography methodology with an isocratic mobile phase.
Public/Granted literature
- US12078621B2 Automated semi-preparative gradient recycling liquid chromatography Public/Granted day:2024-09-03
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