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    DUAL MODE SAMPLE MANAGER
    2.
    发明申请
    DUAL MODE SAMPLE MANAGER 审中-公开

    公开(公告)号：US20200309743A1

    公开(公告)日：2020-10-01

    申请号：US16826667

    申请日：2020-03-23

    申请人： Waters Technologies Corporation

    发明人： Sylvain Gilles Cormier ,  Joseph D. Michienzi

    IPC分类号： G01N30/20 ,  G01N30/38 ,  G01N30/32

    摘要： Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

    METHODOLOGY FOR SCALING METHODS BETWEEN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS
    3.
    发明申请
    METHODOLOGY FOR SCALING METHODS BETWEEN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS 审中-公开
    超临界流体色谱系统之间缩放方法的方法

    公开(公告)号：US20160136544A1

    公开(公告)日：2016-05-19

    申请号：US14898014

    申请日：2014-06-12

    申请人： WATERS TECHNOLOGIES CORPORATION

    发明人： Christopher Hudalla

    IPC分类号： B01D15/40 ,  G01N30/32 ,  B01D15/16

    CPC分类号： B01D15/40 ,  B01D15/16 ,  B01D15/163 ,  B01J3/02 ,  G01N30/32 ,  G01N30/8658 ,  G01N2030/326

    摘要： A methodology scales supercritical fluid chromatography (SFC) and/or carbon dioxide based chromatography methods between different system and/or column configurations. The methodology includes measuring an average mobile phase density during a first separation utilizing CO2 as a mo bile phase component and substantially duplicating the average density profile for a second separation. Substantial duplication of the average mobile phase density (e.g., within about 10%, 5%, 2.5%, 1%, 0.5%, 0.1 %, 0.05%) results in chromatography for both system and/or column configurations having similar selectivity and retention factors. Average mobile phase density may be, either measured directly, calculated, or approximated using average pressure or density measurements. The average pressure profile may be used as a close approximation to duplicate average density profiles between separations.

    摘要翻译： A方法在不同系统和/或柱构型之间进行超临界流体色谱（SFC）和/或基于二氧化碳的色谱法的比较。 该方法包括在利用CO 2作为微量相分量的第一分离期间测量平均流动相密度，并基本上复制用于第二分离的平均密度分布。 平均流动相密度的显着重复（例如，在约10％，5％，2.5％，1％，0.5％，0.1％，0.05％之内）导致具有相似选择性和保留性的系统和/或柱构型的色谱法 因素 可以使用平均压力或密度测量直接测量，计算或近似平均流动相密度。 平均压力分布可以用于近似分离之间的重复平均密度分布。

    CHARGED AEROSOL DETECTORS
    5.
    发明公开
    CHARGED AEROSOL DETECTORS 审中-公开

    公开(公告)号：US20240345037A1

    公开(公告)日：2024-10-17

    申请号：US18634339

    申请日：2024-04-12

    申请人： Waters Technologies Corporation

    发明人： Joseph A. Jarrell

    IPC分类号： G01N30/12 ,  G01N30/02 ,  G01N30/38 ,  G01N30/72 ,  G01N30/74

    CPC分类号： G01N30/12 ,  G01N30/38 ,  G01N30/7233 ,  G01N30/74 ,  G01N2030/027 ,  G01N2030/743

    摘要： Embodiments described herein relate to improved devices and techniques for measuring the charge carried by analyte particles. The charge may be measured in a way that does not destroy the analyte, so that the analyte remains available for further analysis. The charged analyte particles may pass through (or by) an electrode. In doing so, they induce a counter charge on that electrode which can be detected electronically. Subsequent to their passage through that electrode, the particles can be collected on a substrate or may pass in real-time into a mass spectrometer. In some embodiments, both conventional destructive detection and nondestructive detection may both be present in an improved charged aerosol detector and the stream of charged particles may be directed to one or the other by a suitable redirector. Embodiments may be combined with light scattering analysis to provide further non-destructive analysis. Various combinations of these improvements are also described.

    NEEDLE DRIVE, SYSTEM AND METHOD
    10.
    发明公开
    NEEDLE DRIVE, SYSTEM AND METHOD 审中-公开

    公开(公告)号：US20240201142A1

    公开(公告)日：2024-06-20

    申请号：US18586786

    申请日：2024-02-26

    申请人： Waters Technologies Corporation

    发明人： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson ,  Marc E. Lemelin

    IPC分类号： G01N30/16 ,  G01N35/10

    CPC分类号： G01N30/16 ,  G01N35/1079 ,  G01N35/1095 ,  G01N2035/1027

    摘要： A liquid chromatography sample manager includes a thermal chamber, a sample platter mounted in the thermal chamber, and a needle drive including a base having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle, and a drive system attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle. The liquid chromatography sample manager further includes a sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.