Data transmission mitigating interwire crosstalk including: dividing a data block to be transmitted from a transmitter to a receiver across a set of signal wires into sub-blocks; encoding each of the sub-blocks into a plurality of codewords; selecting, for each sub-block by a cost function, one of the codewords that is less likely to introduce interwire crosstalk; transmitting the selected codewords; and updating the cost function at the transmitter with feedback from the receiver.