The disclosure relates to a method and apparatus for transmitting and receiving a signal in a wireless communication system. An operating method of a terminal in a wireless communication system includes receiving, from a base station, information related to a position of a symbol in which a synchronization signal block is transmitted in a time domain, determining whether a position of a symbol configured to transmit an uplink signal overlaps the position of the symbol in which the synchronization signal block is transmitted in the time domain, in case that the position of the symbol configured to transmit the uplink signal overlaps the position of the symbol in which the synchronization signal block is transmitted in the time domain, determining whether a time or frequency-division duplexing (XDD)-related indicator is configured or received, and transmitting the uplink signal to the base station, based on a result of the determining whether the XDD-related indicator is configured or received.