- 专利标题： BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
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申请号： US17302310申请日： 2021-04-29
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公开(公告)号： US20220347302A1公开(公告)日： 2022-11-03
- 发明人: Martin Maier , Muthusamy Jayaraman , Akin Akinc , Shigeo Matsuda , Pachamuthu Kandasamy , Kallanthottathil G. Rajeev , Muthiah Manoharan
- 申请人： ALNYLAM PHARMACEUTICALS, INC.
- 申请人地址： US MA Cambridge
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K47/18
- IPC分类号： A61K47/18 ; A61K9/127 ; A61K9/51 ; A61K31/713 ; C07D317/30 ; C07C211/09 ; C07C211/10 ; C07C211/11 ; C07C217/08 ; C07C229/12 ; C07C327/22 ; C07C327/28 ; C07C327/32 ; C07C235/06 ; C07C251/38 ; C07F5/02 ; C07D233/54 ; C07D207/32 ; C07D295/08 ; C07D295/12 ; C07D295/14 ; C07C323/12 ; C07C323/58 ; C07C31/125 ; A61K31/7088 ; A61K31/7105
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
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