Patent search ipc:"C07C327/22" Page 1

1.

发明公开
BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开

公开(公告)号：US20240285767A1

公开(公告)日：2024-08-29

申请号：US18589636

申请日：2024-02-28

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Martin MAIER , Muthusamy JAYARAMAN , Akin AKINC , Shigeo MATSUDA , Pachamuthu KANDASAMY , Kallanthottathil G. RAJEEV , Muthiah MANOHARAN , Jayaprakash K. NAIR , Thomas A. BAILLIE

IPC: A61K47/18 , A61K9/127 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/713 , C07C31/125 , C07C211/09 , C07C211/10 , C07C211/11 , C07C217/08 , C07C229/12 , C07C235/06 , C07C251/38 , C07C323/12 , C07C323/58 , C07C327/22 , C07C327/28 , C07C327/32 , C07D207/32 , C07D233/54 , C07D295/08 , C07D295/12 , C07D295/14 , C07D317/30 , C07F5/02

CPC classification number: A61K47/18 , A61K9/1272 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/713 , C07C31/125 , C07C211/09 , C07C211/10 , C07C211/11 , C07C217/08 , C07C229/12 , C07C235/06 , C07C251/38 , C07C323/12 , C07C323/58 , C07C327/22 , C07C327/28 , C07C327/32 , C07D207/32 , C07D233/54 , C07D295/08 , C07D295/12 , C07D295/14 , C07D317/30 , C07F5/022

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

2.

发明公开
Cationic Lipid Compound and Composition for Delivery of Nucleic Acids and Use Thereof 审中-公开

公开(公告)号：US20240180836A1

公开(公告)日：2024-06-06

申请号：US18410875

申请日：2024-01-11

Applicant: Shenzhen Rhegen Biotechnology Co., Ltd. , Wuhan Rhegen Biotechnology Co.,Ltd.

Inventor： Yong HU , Yafei LI , Zhaoyu HU

IPC: A61K9/127 , A61K38/18 , A61K48/00 , C07C327/22 , C07C327/30

CPC classification number: A61K9/1272 , A61K38/1816 , A61K48/0033 , C07C327/22 , C07C327/30

Abstract: The cationic lipid compound and composition for delivering nucleic acids as shown in formula (I) and their use are disclosed. The use of nano lipid particles with the compound as a key component in nucleic acid delivery is also disclosed, including the composition, preparation method, and usage method of the delivery carrier.

3.

发明申请
BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS 有权

公开(公告)号：US20220175930A1

公开(公告)日：2022-06-09

申请号：US17651038

申请日：2022-02-14

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin Maier , Muthusamy Jayaraman , Akin Akinc , Shigeo Matsuda , Pachamuthu Kandasamy , Kallanthottathil G. Rajeev , Muthiah Manoharan

IPC: A61K47/18 , A61K9/127 , A61K9/51 , A61K31/713 , C07D317/30 , C07C211/09 , C07C211/10 , C07C211/11 , C07C217/08 , C07C229/12 , C07C327/22 , C07C327/28 , C07C327/32 , C07C235/06 , C07C251/38 , C07F5/02 , C07D233/54 , C07D207/32 , C07D295/08 , C07D295/12 , C07D295/14 , C07C323/12 , C07C323/58 , C07C31/125 , A61K31/7088 , A61K31/7105

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

4.

发明申请
BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS 有权

公开(公告)号：US20220175928A1

公开(公告)日：2022-06-09

申请号：US17651023

申请日：2022-02-14

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin Maier , Muthusamy Jayaraman , Akin Akinc , Shigeo Matsuda , Pachamuthu Kandasamy , Kallanthottathil G. Rajeev , Muthiah Manoharan

IPC: A61K47/18 , A61K9/127 , A61K9/51 , A61K31/713 , C07D317/30 , C07C211/09 , C07C211/10 , C07C211/11 , C07C217/08 , C07C229/12 , C07C327/22 , C07C327/28 , C07C327/32 , C07C235/06 , C07C251/38 , C07F5/02 , C07D233/54 , C07D207/32 , C07D295/08 , C07D295/12 , C07D295/14 , C07C323/12 , C07C323/58 , C07C31/125 , A61K31/7088 , A61K31/7105

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

5.

发明申请
BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS 有权

公开(公告)号：US20220125927A1

公开(公告)日：2022-04-28

申请号：US17573878

申请日：2022-01-12

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin Maier , Muthusamy Jayaraman , Akin Akinc , Shigeo Matsuda , Pachamuthu Kandasamy , Kallanthottathil G Rajeev , Muthiah Manoharan

IPC: A61K47/18 , C07C323/58 , C07C327/28 , A61K31/713 , C07C323/12 , C07D233/54 , C07D295/12 , C07D295/14 , A61K9/51 , C07C31/125 , C07C211/09 , C07C235/06 , A61K31/7088 , C07C211/10 , C07C217/08 , C07D295/08 , C07D317/30 , A61K31/7105 , C07C327/22 , C07C327/32 , C07F5/02 , C07C211/11 , C07C251/38 , A61K9/127 , C07C229/12 , C07D207/32

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

6.

发明申请
ANALOGUES OF OLEUROPEIN AND OLEACEIN AND USES THEREOF 有权

公开(公告)号：US20220110962A1

公开(公告)日：2022-04-14

申请号：US17500099

申请日：2021-10-13

Applicant: Attica Sciences Ltd.

Inventor： Dimitrios ILIOPOULOS

IPC: A61K31/7048 , A61P35/00 , A61P37/06 , C07H17/04 , C07C69/738 , C07D209/12 , C07C327/22 , C07C321/14 , A61K31/22 , A61K31/222 , A61K31/404 , A61K31/265 , A61K31/282 , A61K33/243 , A61K31/475 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/407 , A61K31/513 , A61K31/519 , A61K31/7068 , A61K38/20 , A61K35/17

Abstract: Analogues of oleuropein and oleacein and pharmaceutically acceptable salts thereof and processes for the preparation of these compounds are disclosed. The invention further relates to use of oleuropein and oleacein analogues for the treatment of inflammatory disorders, cardiometabolic disorders, and cancer.

7.

发明授权
Hydrophilic metal surface treatment agent 有权

公开(公告)号：US11124881B2

公开(公告)日：2021-09-21

申请号：US17272765

申请日：2020-06-04

Applicant: CHEMICAL DENSHI CO., LTD. , Tokushima University

Inventor： Shoichi Yamada , Toshio Hyuga , Hisao Nemoto

IPC: C23F11/12 , C07D319/06 , C23F11/16 , C07C327/22 , C07D317/20

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n+1 valent linker group, n is an integer of 1 or more and 5 or less.

8.

发明申请
METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE 审中-公开

公开(公告)号：US20200087255A1

公开(公告)日：2020-03-19

申请号：US16687394

申请日：2019-11-18

Applicant: CALITHERA BIOSCIENCES, INC.

Inventor： Michael C. VAN ZANDT , Jennifer L. SAVOY

IPC: C07D207/16 , C07C327/22 , C07C231/12 , C07D207/06 , C07F5/02 , C07C235/06 , C07C233/65 , C07B57/00 , C07C233/57 , C07C233/05

Abstract: A method is provided to conveniently separate racemic (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide and (3S,4R)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide using selective crystallization with chiral carboxylic acids.

9.

发明授权
Method for producing carboxylic acid thioester 有权

公开(公告)号：US10377706B2

公开(公告)日：2019-08-13

申请号：US15988300

申请日：2018-05-24

Applicant: Mitsubishi Chemical Corporation

Inventor： Akihiro Goto

IPC: C07C327/06 , C07C327/22 , C07C327/24 , C07C327/26 , C07C327/32 , C07D213/70 , C07C327/08 , C07D277/74 , C07B61/00

Abstract: According to the present invention, there is provided a method for producing carboxylic acid thioester, comprising reacting a compound represented by the following formula (I), carboxylic acid and thiol in the presence of a catalyst including at least one Group 2 metal compound. The production method is a production method which is simple in reaction operation, which places a small load on the environment and the human body and which enables carboxylic acid thioester to be catalytically obtained at a high yield even at a normal temperature and a normal pressure (25° C., 1 atm). In the formula (I), R1 and R2 each independently represent a hydrocarbon group having 1 to 20 carbon atoms.