- 专利标题: CHIMERIC ANTIGEN RECEPTOR
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申请号: US17746642申请日: 2022-05-17
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公开(公告)号: US20220356260A1公开(公告)日: 2022-11-10
- 发明人: Martin Pulé , Shaun Cordoba , Simon Thomas , Shimobi Onuoha , Mathieu Ferrari , Wen Chean Lim , Biao Ma
- 申请人: AUTOLUS LIMITED
- 申请人地址: GB London
- 专利权人: AUTOLUS LIMITED
- 当前专利权人: AUTOLUS LIMITED
- 当前专利权人地址: GB London
- 优先权: GB1815775.0 20180927,GB1902021.3 20190214
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; A61P35/00 ; A61K35/17
摘要:
The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.
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