Methods and apparatus are disclosed to protect secure assets using scan operations. One example apparatus includes logic circuitry including a scan chain that includes data storage elements and design logic coupled to the scan chain. The example apparatus also includes data storage to store secure data. The design logic is coupled to the data storage. The example apparatus also includes a security controller to transition the apparatus out of a secure mode of operation. The transition includes the security controller to cause the scan chain to serially shift secure scan data from an input of the scan chain into each data storage element of the data storage elements of the scan chain.