A method and system enable to-be-processed medical image data and its corresponding noise characteristic information to be normalized to resemble noise characteristic information of training data used to train at least one neural network for at least one ultrasound data acquisition mode. After normalizing, this processed medical image data is input into the trained neural network for producing output data used for generating cleaner images. Noise characteristic information can be used directly in training a neural network, generating a trained neural network that can handle medical image data with various noise characteristics.