Systems and methods are provided for assembling and operating an electrode assembly for a redox flow battery system. In one example, the electrode assembly may include an inflatable housing in which a negative electrode spacer and a positive electrode may be positioned, wherein the inflatable housing may inflate responsive to applied internal pressure during operation of the redox flow battery system. In some examples, the electrode assembly may be assembled via roll-to-roll processing and may be mechanically and fluidically coupled to electrode assemblies of like configuration. In this way, tolerance stacking may be decreased, processing may be simplified, and costs may be reduced relative to molding-based processes for electrode assembly manufacturing.