A portable oropharyngeal swab smart collection device, which includes a collection device body, a remote control module, and a visual display unit, where a main control unit and an execution unit and a visual unit which are electrically connected with the main control unit respectively are arranged on the collection device body; a detachable oropharyngeal swab collector is arranged on the execution unit; the remote control module includes remote operation equipment which is in communication connection with the main control unit; and the visual display unit is in communication connection with the main control unit and the visual unit. The portable oropharyngeal swab smart collection device of the present disclosure can implement a collection by a oropharyngeal swab through remote control, rather than a face-to-face artificial collection by the oropharyngeal swab by a medical staff to a suspected patient with an infectious disease.