The present invention relates to a temperature-change sensing substrate comprising a self-healing polyurethane polymer. More specifically, the present invention relates to a temperature-change sensing substrate having a self-healing polyurethane polymer matrix and a plurality of pores dispersed in the matrix. The temperature-change sensing substrate according to the present invention can be applied as a temperature-change sensor for preventing the spoiling of refrigerated or frozen food and medical supplies. For example, substrate, which was opaque when stored at −60° C., −50° C., −30° C., −20° C., −10° C. and the like, becomes transparent if the temperature rises to 0° C., 10° C., 20° C., 30° C. and the like, and thus a temperature-change sensor capable of checking storage conditions through a change in light transmittance can be provided.