- 专利标题： ACTIVATING PYRUVATE KINASE R
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申请号： US17761795申请日： 2020-09-18
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公开(公告)号： US20220378756A1公开(公告)日： 2022-12-01
- 发明人: Anna Ericsson , Sanjeev Forsyth , Neal Green , Gary Gustafson , Patrick F. Kelly , David R. Lancia, JR. , Gary Marshall , Lorna Mitchell , Madhu Mondal , Maria Ribadeneira , David Richard , Patricia Schroeder , Zhongguo Wang
- 申请人： FORMA Therapeutics, Inc.
- 申请人地址： US MA Watertown
- 专利权人： FORMA Therapeutics, Inc.
- 当前专利权人： FORMA Therapeutics, Inc.
- 当前专利权人地址： US MA Watertown
- 优先权： WOPCTUS2019052024 20190919
- 国际申请： PCT/US2020/051579 WO 20200918
- 主分类号： A61K31/436
- IPC分类号： A61K31/436 ; A61K9/48 ; A61K9/00 ; A61P7/06
摘要：
The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrroll-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.
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