- 专利标题： METHOD FOR TREATING TYPE I DIABETES WITH PEPTIDE-LOADED DENDRITIC CELLS
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申请号： US17827069申请日： 2022-05-27
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公开(公告)号： US20220378835A1公开(公告)日： 2022-12-01
- 发明人: Hong Jiang
- 申请人： Avotres, Inc.
- 申请人地址： US NJ Cedar Knolls
- 专利权人： Avotres, Inc.
- 当前专利权人： Avotres, Inc.
- 当前专利权人地址： US NJ Cedar Knolls
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C12N5/0784 ; A61P37/04
摘要：
The present invention provides a composition comprising dendritic cells loaded with hHsp60sp, which dendritic cells are from a subject and have been fixed with paraformaldehyde (PFA). The subject may suffer from an autoimmune disease. Also provided are a method for preparing the composition; recombinant human cells comprising a heterologous gene encoding a fusion protein of HLA-E and hHsp60sp or B7sp, and expressing the fusion protein on the surface of the cells; a method for determining a percentage of maximum inhibition of testing the function of the HLA-E restricted CD8+ Treg cells from a subject, determining whether HLA-E restricted CD8+ Treg cells freshly isolated from a subject are defective, or determining whether defective HLA-E restricted CD8+ Treg cells from a subject are correctable; and a method for correcting defective HLA-E restricted CD8+ Treg cells, treating type 1 diabetes (T1D), or treating multiple sclerosis (MS).
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