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7 条记录 (耗时 0.011 秒)

    DETECTION OF A DEFECT ON HLA-E RESTRICTED CD8+ T REGULATORY CELLS
    1.
    发明申请
    DETECTION OF A DEFECT ON HLA-E RESTRICTED CD8+ T REGULATORY CELLS 有权

    公开(公告)号：US20220378836A1

    公开(公告)日：2022-12-01

    申请号：US17827142

    申请日：2022-05-27

    申请人： Avotres, Inc.

    发明人： Hong Jiang

    IPC分类号： A61K35/17 ,  A61P37/02 ,  C07K14/74 ,  C12N5/0783 ,  G01N33/50

    摘要： The present invention provides a composition comprising dendritic cells loaded with hHsp60sp, which dendritic cells are from a subject and have been fixed with paraformaldehyde (PFA). The subject may suffer from an autoimmune disease. Also provided are a method for preparing the composition; recombinant human cells comprising a heterologous gene encoding a fusion protein of HLA-E and hHsp60sp or B7sp, and expressing the fusion protein on the surface of the cells; a method for determining a percentage of maximum inhibition of testing the function of the HLA-E restricted CD8+ Treg cells from a subject, determining whether HLA-E restricted CD8+ Treg cells freshly isolated from a subject are defective, or determining whether defective HLA-E restricted CD8+ Treg cells from a subject are correctable; and a method for correcting defective HLA-E restricted CD8+ Treg cells, treating type 1 diabetes (T1D), or treating multiple sclerosis (MS).

    PREPARATION OF A THERAPEUTIC COMPOSITION FOR TREATING AUTOIMMUNE DISEASES
    5.
    发明申请
    PREPARATION OF A THERAPEUTIC COMPOSITION FOR TREATING AUTOIMMUNE DISEASES 有权

    公开(公告)号：US20220387553A1

    公开(公告)日：2022-12-08

    申请号：US17827089

    申请日：2022-05-27

    申请人： Avotres, Inc.

    发明人： Hong Jiang

    IPC分类号： A61K38/17 ,  A61P25/28 ,  A61P37/06 ,  A61P19/02 ,  A61P17/06 ,  A61K47/20 ,  A61K47/42 ,  A61K35/15

    摘要： The present invention provides a composition comprising dendritic cells loaded with hHsp60sp, which dendritic cells are from a subject and have been fixed with paraformaldehyde (PFA). The subject may suffer from an autoimmune disease. Also provided are a method for preparing the composition; recombinant human cells comprising a heterologous gene encoding a fusion protein of HLA-E and hHsp60sp or B7sp, and expressing the fusion protein on the surface of the cells; a method for determining a percentage of maximum inhibition of testing the function of the HLA-E restricted CD8+ Treg cells from a subject, determining whether HLA-E restricted CD8+ Treg cells freshly isolated from a subject are defective, or determining whether defective HLA-E restricted CD8+ Treg cells from a subject are correctable; and a method for correcting defective HLA-E restricted CD8+ Treg cells, treating type 1 diabetes (T1D), or treating multiple sclerosis (MS).

    METHOD FOR TREATING TYPE I DIABETES WITH PEPTIDE-LOADED DENDRITIC CELLS
    6.
    发明申请
    METHOD FOR TREATING TYPE I DIABETES WITH PEPTIDE-LOADED DENDRITIC CELLS 有权

    公开(公告)号：US20220378835A1

    公开(公告)日：2022-12-01

    申请号：US17827069

    申请日：2022-05-27

    申请人： Avotres, Inc.

    发明人： Hong Jiang

    IPC分类号： A61K35/17 ,  C12N5/0784 ,  A61P37/04

    摘要： The present invention provides a composition comprising dendritic cells loaded with hHsp60sp, which dendritic cells are from a subject and have been fixed with paraformaldehyde (PFA). The subject may suffer from an autoimmune disease. Also provided are a method for preparing the composition; recombinant human cells comprising a heterologous gene encoding a fusion protein of HLA-E and hHsp60sp or B7sp, and expressing the fusion protein on the surface of the cells; a method for determining a percentage of maximum inhibition of testing the function of the HLA-E restricted CD8+ Treg cells from a subject, determining whether HLA-E restricted CD8+ Treg cells freshly isolated from a subject are defective, or determining whether defective HLA-E restricted CD8+ Treg cells from a subject are correctable; and a method for correcting defective HLA-E restricted CD8+ Treg cells, treating type 1 diabetes (T1D), or treating multiple sclerosis (MS).

    A METHOD FOR TREATING MULTIPLE SCLEROSIS WITH PEPTIDE-LOADED DENDRITIC CELLS
    7.
    发明申请
    A METHOD FOR TREATING MULTIPLE SCLEROSIS WITH PEPTIDE-LOADED DENDRITIC CELLS 有权

    公开(公告)号：US20220378825A1

    公开(公告)日：2022-12-01

    申请号：US17827077

    申请日：2022-05-27

    申请人： Avotres, Inc.

    发明人： Hong Jiang

    IPC分类号： A61K35/15 ,  A61K38/17 ,  A61K38/38 ,  A61K31/10 ,  C12N5/0784

    摘要： The present invention provides a composition comprising dendritic cells loaded with hHsp60sp, which dendritic cells are from a subject and have been fixed with paraformaldehyde (PFA). The subject may suffer from an autoimmune disease. Also provided are a method for preparing the composition; recombinant human cells comprising a heterologous gene encoding a fusion protein of HLA-E and hHsp60sp or B7sp, and expressing the fusion protein on the surface of the cells; a method for determining a percentage of maximum inhibition of testing the function of the HLA-E restricted CD8+ Treg cells from a subject, determining whether HLA-E restricted CD8+ Treg cells freshly isolated from a subject are defective, or determining whether defective HLA-E restricted CD8+ Treg cells from a subject are correctable; and a method for correcting defective HLA-E restricted CD8+ Treg cells, treating type 1 diabetes (T1D), or treating multiple sclerosis (MS).