发明申请
- 专利标题： SMALL EXTRACELLULAR VESICLE-ASSOCIATED VEGF AS A PREDICTOR FOR THERAPEUTIC RESPONSES
-
申请号： US17769826申请日： 2020-10-16
-
公开(公告)号： US20220390456A1公开(公告)日： 2022-12-08
- 发明人: Honami NAORA , Song Yi KO
- 申请人： Board of Regents, The University of Texas System
- 申请人地址： US TX Austin
- 专利权人： Board of Regents, The University of Texas System
- 当前专利权人： Board of Regents, The University of Texas System
- 当前专利权人地址： US TX Austin
- 国际申请： PCT/US2020/055922 WO 20201016
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; G01N33/74 ; C07K16/22 ; A61K45/06
摘要：
Provided herein are methods for predicting whether a cancer patient will respond to treatment with bevacizumab based on determining a level of small extracellular vesicle (sEV)-associated VEGF in the patient. Also provided are methods of treating patients with either bevacizumab or a VEGFR tyrosine kinase inhibitor, a VEGFR neutralizing antibody, or a VEGF ligand trap based on the level of small extracellular vesicle (sEV)-associated VEGF in the patient.
信息查询
IPC分类:
