- 专利标题: CONTROLLED RELEASE SOLID DOSE FORMS
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申请号: US17716200申请日: 2022-04-08
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公开(公告)号: US20220401370A1公开(公告)日: 2022-12-22
- 发明人: JUERGEN SIEPMANN , YVONNE CUPPOK
- 申请人: DUPONT NUTRITION USA, INC.
- 申请人地址: US DE Wilmington
- 专利权人: DUPONT NUTRITION USA, INC.
- 当前专利权人: DUPONT NUTRITION USA, INC.
- 当前专利权人地址: US DE Wilmington
- 主分类号: A61K9/28
- IPC分类号: A61K9/28
摘要:
The present invention is directed to a solid dose form comprising a film coating composition encapsulating a core, wherein: (i) the core comprises an active ingredient comprising at least one of a pharmaceutical, veterinary, or nutraceutical active ingredient; (ii) the film coating composition comprises ethylcellulose and guar gum, wherein the guar gum has an apparent viscosity ≥151.0 cps at a shear rate of 50 s−1 in a 1% aqueous guar gum solution measured rotationally at 20° C. after 1 minute equilibration using a 6 cm acrylic cone (1°) on a cone-plate viscometer wherein the shear is ramped up linearly from 1 to 50 s−1 in 25 steps over 29 seconds; (iii) the dose form provides controlled release of the active ingredient; (iv) the guar gum is present in an amount greater than 5 wt % based on the weight of the guar gum and ethylcellulose; and (v) the dose form is ethanol resistant.
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