利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.027 秒)

    CONTROLLED RELEASE SOLID DOSE FORMS
    3.
    发明申请
    CONTROLLED RELEASE SOLID DOSE FORMS 有权

    公开(公告)号：US20220401370A1

    公开(公告)日：2022-12-22

    申请号：US17716200

    申请日：2022-04-08

    申请人： DUPONT NUTRITION USA, INC.

    发明人： JUERGEN SIEPMANN ,  YVONNE CUPPOK

    IPC分类号： A61K9/28

    摘要： The present invention is directed to a solid dose form comprising a film coating composition encapsulating a core, wherein: (i) the core comprises an active ingredient comprising at least one of a pharmaceutical, veterinary, or nutraceutical active ingredient; (ii) the film coating composition comprises ethylcellulose and guar gum, wherein the guar gum has an apparent viscosity ≥151.0 cps at a shear rate of 50 s−1 in a 1% aqueous guar gum solution measured rotationally at 20° C. after 1 minute equilibration using a 6 cm acrylic cone (1°) on a cone-plate viscometer wherein the shear is ramped up linearly from 1 to 50 s−1 in 25 steps over 29 seconds; (iii) the dose form provides controlled release of the active ingredient; (iv) the guar gum is present in an amount greater than 5 wt % based on the weight of the guar gum and ethylcellulose; and (v) the dose form is ethanol resistant.

    A COLLOIDAL STABILIZER EFFECTIVE AT LOW CONCENTRATIONS
    4.
    发明申请
    A COLLOIDAL STABILIZER EFFECTIVE AT LOW CONCENTRATIONS 审中-公开

    公开(公告)号：US20190174785A1

    公开(公告)日：2019-06-13

    申请号：US16323415

    申请日：2017-08-11

    申请人： DUPONT NUTRITION USA, INC.

    发明人： Zheng Tan ,  Mei Yan Joyce Toh ,  Simon Patrick Charles Eustace ,  Jeremy Ondov

    IPC分类号： A23C9/154 ,  C08L1/04 ,  A23L2/52 ,  A23L29/262

    摘要： This invention relates to making and using a stabilizer that is effective in small amounts and, particularly useful for stabilizing low solids liquids, e.g., dispersions, emulsions, and suspensions, used in foods, pharmaceuticals, nutraceuticals, and similar industrial applications, which comprises, microcrystalline cellulose, (preferably, colloidal hydrolyzed MCC); a first carboxymethyl cellulose having a viscosity of 30-85 cP at 2% in deionized water; and, a degree of carboxymethyl substitutions of 0.60 to 0.85, and a second carboxymethyl cellulose having a viscosity of 400-800 cP at 2% in deionized water, and a degree of carboxymethyl substitutions of 0.80 to 0.95; and, the stabilizer may be made by preparing a moist MCC “wetcake”; thoroughly mixing the wetcake with a dry blended mixture of low DS and medium DS, CMCs; preferably, in a MCC/low DS CMC/medium DS CMC ratio range of about 88/6/6 to about 92/4/4, adding that mixture to an extruder; preparing a slurry of the extrudate in deionized water; and, optionally, pumping the slurry to a spray dryer to produce a powder.

    ETHYLCELLULOSE FORMULATIONS AND METHODS OF MAKING SAME
    5.
    发明申请
    ETHYLCELLULOSE FORMULATIONS AND METHODS OF MAKING SAME 审中-公开

    公开(公告)号：US20190038540A1

    公开(公告)日：2019-02-07

    申请号：US16054175

    申请日：2018-08-03

    申请人： DUPONT NUTRITION USA, INC.

    发明人： Hui S. YANG ,  HUA MA

    IPC分类号： A61K8/73 ,  A61K8/44 ,  A61Q19/00 ,  A61Q1/04 ,  A61Q17/04 ,  A61Q1/02 ,  A61K8/06

    摘要： Ethylcellulose dispersions in water are film forming compositions that have found use in personal care applications. Conventional methods can require that aqueous dispersions of water-insoluble polymers such as ethylcellulose be obtained using surfactants such as sodium lauryl sulfate (SLS). There is a desire to reduce the degree of consumer exposure to SLS in personal care products. The present invention describes ethylcellulose dispersions comprising surfactants to substantially replace sodium lauryl sulfate. The present invention also describes methods of reducing or substantially eliminating SLS in personal care products that comprise ethylcellulose dispersions.

    CONTROLLED RELEASE COMPOSITION AND METHOD
    7.
    发明申请
    CONTROLLED RELEASE COMPOSITION AND METHOD 审中-公开

    公开(公告)号：US20180360763A1

    公开(公告)日：2018-12-20

    申请号：US16054019

    申请日：2018-08-03

    申请人： DUPONT NUTRITION USA, INC.

    发明人： HUI S. YANG ,  HUA MA ,  KEVIN STOKES

    IPC分类号： A61K9/50 ,  A61K31/554 ,  A61K31/522 ,  A61K9/28

    摘要： In one aspect, the present invention is directed to a method of making a controlled release solid dosage form having an ethylcellulose coating layer, which layer comprises a coalescing agent which is an organic ester having an HLB Value of from 3 to 8. The use of such coalescing agent permits the formation of an effective controlled release coating without the need for a further curing step after the coating process. In other aspects, this invention relates to an aqueous dispersion useful in such method; as well as to the coated dosage form produced.