- 专利标题： CD4 MIMIC COMPOUND WITH ANTI-HIV ACTIVITY
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申请号： US17755366申请日： 2020-10-29
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公开(公告)号： US20220409594A1公开(公告)日： 2022-12-29
- 发明人: Shuzo MATSUSHITA , Kazuhisa YOSHIMURA , Hirokazu TAMAMURA , Ami MASUDA , Kohei TAKAHASHI , Takuya KOBAYAKAWA , Shigeyoshi HARADA , Tomoyuki MIURA
- 申请人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIONS DISEASES
- 申请人地址： JP Kumamoto-shi, Kumamoto; JP Tokyo; JP Tokyo
- 专利权人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY,JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIONS DISEASES
- 当前专利权人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY,JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIONS DISEASES
- 当前专利权人地址： JP Kumamoto-shi, Kumamoto; JP Tokyo; JP Tokyo
- 优先权： JP2019-195967 20191029
- 国际申请： PCT/JP2020/040611 WO 20201029
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D221/20 ; A61K39/42
摘要：
CD4 mimic compounds having improved efficacy for anti-HIV treatment and more improved pharmacokinetics are provided. The compounds are represented by formula (I): wherein R1 is C2H4(OC2H4)n—OCH3 or CmH2m+1; R2 is O or NH; n is 3 to 25; and m is 4 to 22, or a salt thereof. HIV infection inhibitor compositions including the compound or a salt thereof as an active ingredient are also disclosed.
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