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公开(公告)号：US20240316250A1
公开(公告)日：2024-09-26
申请号：US18734282
申请日：2024-06-05
申请人： NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , SAPPORO MEDICAL UNIVERSITY , ADEKA CORPORATION , KM Biologics Co., Ltd.
发明人： Junichi MATSUDA , Sumika MIYABASHIRA , Satomi HARANO , Akio KISHIDA , Tsuyoshi KIMURA , Jun NEGISHI , Tetsuya HIGAMI , Seiichi FUNAMOTO , Ken-Ichiro HIWATARI , Akiko TASAKI
IPC分类号： A61L27/52 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/42 , A61K38/36 , A61K38/48 , A61L27/22 , A61L27/26 , A61L27/36 , A61L27/54 , C12N5/00
CPC分类号： A61L27/52 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/42 , A61K38/363 , A61K38/4833 , A61L27/225 , A61L27/26 , A61L27/3633 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/54 , C12N5/0068 , A61L2430/00 , A61L2430/20 , A61L2430/32 , C12N2533/50 , C12N2533/56 , C12N2533/90
摘要： A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.
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公开(公告)号：US20240285373A1
公开(公告)日：2024-08-29
申请号：US18558824
申请日：2022-05-06
发明人： Wataru Komada , Shinya Oishi
IPC分类号： A61C5/35
CPC分类号： A61C5/35
摘要： A dental abutment construction member which is used for the construction of abutments is configured so as to have a tubular shape having an upper surface, a bottom surface, an outer peripheral side surface and an inner peripheral side surface. According to this configuration, the concentration of stress in cervical areas can be prevented and the formation of post holes becomes unnecessary.
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3.发明公开公开(公告)号：US20240206769A1
公开(公告)日：2024-06-27
申请号：US18396312
申请日：2023-12-26
发明人： Makoto YASUKAWA , Shuhel NOYORI , Akimoto NIMURA , Koji FUJITA , Takuya IBARA
摘要： An information processing apparatus and the like capable of calculating a respiratory feature amount necessary for evaluating a breathing motor function of a subject is provided. The information processing apparatus inputs time-series distance image data acquired by measuring a distance from the subject during a breathing exercise and division position data indicating a position at which a chest region and an abdominal region of the subject are divided in the time-series distance image data. The information processing apparatus calculates a standard deviation image indicating a standard deviation of values for each pixel in a distance image indicated by the time-series distance image data. The information processing apparatus calculates a respiratory feature amount indicating a feature of breathing of the subject, based on a divided standard deviation image acquired by dividing the standard deviation image for each divided region being divided at a position indicated by the division position data.
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公开(公告)号：US20240034836A1
公开(公告)日：2024-02-01
申请号：US18036492
申请日：2021-11-10
IPC分类号： C08G65/334 , C12N5/077
CPC分类号： C08G65/334 , C12N5/0658 , C12N2533/30
摘要： A coating agent including a polyrotaxane represented by Formula (1):
wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500,
is a cyclodextrin in which at least one hydroxyl group is modified with R2, and R2 is a C1-6 alkyl group.-
公开(公告)号：US20240025985A1
公开(公告)日：2024-01-25
申请号：US18256222
申请日：2021-12-06
发明人： Hitoshi Okazawa
CPC分类号： C07K16/24 , A61P25/28 , C07K2317/21
摘要： An object of the present invention is to provide an agent for preventing or treating frontotemporal lobar degeneration which does not cause noticeable adverse reactions and exhibits an excellent effect of preventing and treating frontotemporal lobar degeneration caused by different factors. In the present invention, a human monoclonal antibody that specifically binds to human HMGB1, which comprises heavy chain CDR1, heavy chain CDR2, and heavy chain CDR3 each consisting of a specific amino acid sequence and light chain CDR1, light chain CDR2, and light chain CDR3 each consisting of a specific amino acid sequence, can be used as an agent for preventing or treating frontotemporal lobar degeneration.
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6.发明公开公开(公告)号：US20230414669A1
公开(公告)日：2023-12-28
申请号：US18463631
申请日：2023-09-08
发明人： Kentaro NAKAMURA , Shunsuke TOMINAGA , Ichiro SEKIYA , Mitsuru MIZUNO , Hisako KATANO , Nobutake OZEKI
CPC分类号： A61K35/28 , C12N5/0668 , G01N1/4044 , A61P19/02 , G06T7/60 , G06T7/0012 , G06T2207/30024
摘要： There are provided a production method for a therapeutic agent for arthrosis, in which a population including a plurality of mesenchymal stem cells being cultured is imaged to acquire a cell image, the cell image is analyzed to derive density information on the mesenchymal stem cells in the cell image, colonies, which are formed by the mesenchymal stem cells in the population, are detected based on the density information, and the population is sorted based on at least one of an average colony size or a colony forming unit, which is derived from the detected colonies, and provided a therapeutic agent for arthrosis, which is produced by the production method for a therapeutic agent for arthrosis.
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公开(公告)号：US20230384291A1
公开(公告)日：2023-11-30
申请号：US18029026
申请日：2021-09-28
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： Takanori TAKEBE , Norikazu SAIKI
CPC分类号： G01N33/5082 , C12N5/0697 , C12M21/08 , C12M25/04 , C12N2501/119 , C12N2501/16 , C12N2513/00
摘要： The present invention provides means for producing a parathyroid gland organoid. A culture method of the present invention includes a cell population containing a parathyroid gland cell in a ratio of 50% or more, and a mesenchymal cell in a ratio of 10% or more; and a step of culturing the cell population.
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公开(公告)号：US11819570B2
公开(公告)日：2023-11-21
申请号：US17055032
申请日：2019-05-31
申请人： National University Corporation Tokai National Higher Education and Research System , National University Corporation Tokyo Medical and Dental University
发明人： Takayoshi Suganami , Miyako Tanaka , Akira Matsumoto , Hiroko Matsumoto , Yuki Morooka , Yuji Miyahara
CPC分类号： A61K9/06 , A61K38/28 , A61K47/32 , A61M37/0015 , A61M2037/0023
摘要： A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.
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公开(公告)号：US20230192787A1
公开(公告)日：2023-06-22
申请号：US18113369
申请日：2023-02-23
发明人： Hitoshi OKAZAWA
IPC分类号： C07K14/47 , C12Q1/48 , G01N33/68 , A61K31/44 , A61K31/4439 , A61K31/506 , A61K38/16 , A61K38/02
CPC分类号： C07K14/4703 , C12Q1/485 , G01N33/6896 , A61K31/44 , A61K31/4439 , A61K31/506 , A61K38/16 , A61K38/02 , G01N2800/2821 , A61K31/437
摘要： It has been revealed that, from a pre-onset stage of Alzheimer's disease, enhancement of phosphorylations of MARCKS and the like causes abnormal spine formation or the like, consequently developing the disease. It also has been revealed that the phosphorylations of MARCKS and the like are caused by PKC and the like, and further that b-raf is involved in phosphorylation of tau protein important for the progression of Alzheimer's disease. Thus, these proteins have been found to be target molecules useful in the diagnosis and treatment of Alzheimer's disease. In addition, it has also been revealed that, in a pre-onset stage of frontotemporal lobar degeneration, b-RAF phosphorylation enhancement causes a decrease in the number of spines and the like, consequently developing the disease. Thus, b-RAF has been found to be a target molecule useful in the diagnosis and treatment of frontotemporal lobar degeneration.
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公开(公告)号：US20220409594A1
公开(公告)日：2022-12-29
申请号：US17755366
申请日：2020-10-29
申请人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIONS DISEASES
发明人： Shuzo MATSUSHITA , Kazuhisa YOSHIMURA , Hirokazu TAMAMURA , Ami MASUDA , Kohei TAKAHASHI , Takuya KOBAYAKAWA , Shigeyoshi HARADA , Tomoyuki MIURA
IPC分类号： A61K31/438 , C07D221/20 , A61K39/42
摘要： CD4 mimic compounds having improved efficacy for anti-HIV treatment and more improved pharmacokinetics are provided. The compounds are represented by formula (I): wherein R1 is C2H4(OC2H4)n—OCH3 or CmH2m+1; R2 is O or NH; n is 3 to 25; and m is 4 to 22, or a salt thereof. HIV infection inhibitor compositions including the compound or a salt thereof as an active ingredient are also disclosed.
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