Invention Publication
- Patent Title: COMPOSITIONS AND METHODS FOR INCREASING OR ENHANCING TRANSDUCTION OF GENE THERAPY VECTORS AND FOR REMOVING OR REDUCING IMMUNOGLOBULINS
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Application No.: US17862622Application Date: 2022-07-12
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Publication No.: US20230142731A1Publication Date: 2023-05-11
- Inventor: Sébastien LACROIX-DESMAZES , Federico MINGOZZI , Jordan DIMITROV , Christian LEBORGNE , Sean ARMOUR
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , GENETHON , SORBONNE UNIVERSITÉ , UNIVERSITÉ DE PARIS , SPARK THERAPEUTICS, INC.
- Applicant Address: FR PA Paris
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),GENETHON,SORBONNE UNIVERSITÉ,UNIVERSITÉ DE PARIS,SPARK THERAPEUTICS, INC.
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),GENETHON,SORBONNE UNIVERSITÉ,UNIVERSITÉ DE PARIS,SPARK THERAPEUTICS, INC.
- Current Assignee Address: FR PA Paris
- Priority: WO 305971.6 2018.07.17
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N9/24 ; C12N15/113 ; C12N15/86 ; A61K38/48 ; C12N9/64 ; C12N15/861
Abstract:
Disclosed herein are methods for treating patients that may develop or already have pre-existing gene therapy neutralizing antibodies by administering a protease that cleaves peptide bonds present in immunoglobulins or by administering a glycosidase that cleaves carbohydrate residues present on immunoglobulins, or other similar enzymatic cleavage of immunoglobulins in vivo. Also disclosed are methods for utilizing IdeS and other immunoglobulin G-degrading enzyme polypeptides for gene therapy treatment of a disease in a patient in need thereof.
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