- 专利标题: APPARATUS AND METHOD FOR AIRBORNE PATHOGEN DETECTION USING AN ELECTROCHEMICAL PLATFORM
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申请号: US18055333申请日: 2022-11-14
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公开(公告)号: US20230152320A1公开(公告)日: 2023-05-18
- 发明人: Dipanjan PAN , Maha Mohammad Shehadeh ALAFEEF
- 申请人: University Of Maryland, Baltimore , University of Maryland, Baltimore County
- 申请人地址: US MD Baltimore
- 专利权人: University Of Maryland, Baltimore,University of Maryland, Baltimore County
- 当前专利权人: University Of Maryland, Baltimore,University of Maryland, Baltimore County
- 当前专利权人地址: US MD Baltimore
- 主分类号: G01N33/569
- IPC分类号: G01N33/569 ; G01N29/12 ; G01N29/24 ; G01N33/543
摘要:
An apparatus is provided for airborne pathogen detection, which includes a crystal microbalance. The apparatus includes specific capture probes that are affixed to the crystal microbalance and are designed to bind to and capture a specific pathogen, such as a virus particle. This capture causes a change in mass of the crystal microbalance that can be detected. A method is provided for airborne pathogen detection, which includes calibrating a resonant frequency of the crystal microbalance to a mass on the crystal microbalance. The method also includes a step of conjugating the antibody to the crystal microbalance. The method also includes, for each measurement time, measuring a resonant frequency of the crystal microbalance and determining a mass change due to binding of the pathogen to the detector. This mass change is then related to pathogen load in the medium. A notification is output if the viral load exceeds a predetermined threshold.
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