公开(公告)号：US20230323488A1

公开(公告)日：2023-10-12

申请号：US18298540

申请日：2023-04-11

申请人： University of Maryland, Baltimore County ,  University of Maryland, Baltimore

发明人： Govind RAO ,  Xudong GE ,  Douglas D. FREY ,  Sai Sathish RAMAMURTHY ,  Dipanjan PAN

IPC分类号： C12Q1/70 ,  C12Q1/6844 ,  G01N33/569 ,  G01N1/40 ,  B01L3/00 ,  G01N33/543

CPC分类号： C12Q1/701 ,  C12Q1/6844 ,  G01N33/56983 ,  G01N1/40 ,  B01L3/502761 ,  G01N33/54386 ,  G01N2333/165 ,  B01L2200/0652 ,  B01L2200/16

摘要： The present invention relates to the use of a condensate collector such as portable or stationary dehumidifier placed in a defined testing space or area and used as a readily available and affordable tool to collect airborne virus particles in collected condensate from the testing atmosphere in the defined testing space or area, wherein the collected condensate is analyzed for virus biomarkers to identify viruses, such as SARS-CoV-2 or mutants or variants thereof, in the testing atmosphere.

公开(公告)号：US20230416851A1

公开(公告)日：2023-12-28

申请号：US18247474

申请日：2021-10-05

申请人： University of Maryland, Baltimore ,  University of Maryland, Baltimore County

发明人： Dipanjan PAN ,  Maha Mohammad Shehadeh ALAFEEF ,  Ketan DIGHE ,  Parikshit MOITRA

IPC分类号： C12Q1/70 ,  C12Q1/6825 ,  B01L3/00

CPC分类号： C12Q1/701 ,  C12Q1/6825 ,  B01L3/502715 ,  B01L2300/0663 ,  B01L2200/16

摘要： The present disclosure relates to electrochemical biosensing systems and methods that can be adapted to accurately and rapidly detect a target gene in clinical samples, using anti-sense oligonucleotides for selective detection of biological pathogens.

公开(公告)号：US20230152320A1

公开(公告)日：2023-05-18

申请号：US18055333

申请日：2022-11-14

申请人： University Of Maryland, Baltimore ,  University of Maryland, Baltimore County

发明人： Dipanjan PAN ,  Maha Mohammad Shehadeh ALAFEEF

IPC分类号： G01N33/569 ,  G01N29/12 ,  G01N29/24 ,  G01N33/543

CPC分类号： G01N33/56983 ,  G01N29/12 ,  G01N29/2443 ,  G01N33/54373 ,  G01N2291/014 ,  G01N2291/023 ,  G01N2333/165

摘要： An apparatus is provided for airborne pathogen detection, which includes a crystal microbalance. The apparatus includes specific capture probes that are affixed to the crystal microbalance and are designed to bind to and capture a specific pathogen, such as a virus particle. This capture causes a change in mass of the crystal microbalance that can be detected. A method is provided for airborne pathogen detection, which includes calibrating a resonant frequency of the crystal microbalance to a mass on the crystal microbalance. The method also includes a step of conjugating the antibody to the crystal microbalance. The method also includes, for each measurement time, measuring a resonant frequency of the crystal microbalance and determining a mass change due to binding of the pathogen to the detector. This mass change is then related to pathogen load in the medium. A notification is output if the viral load exceeds a predetermined threshold.