Techniques are described for automating the design of dental restoration appliances using neural networks. An example computing device receives transform information associated with a current dental anatomy of a dental restoration patient, provides the transform information associated with the current dental anatomy of the dental restoration patient as input to a neural network trained with transform information indicating placement of a dental appliance component with respect to one or more teeth of corresponding dental anatomies, the dental appliance being used for dental restoration treatment for the one or more teeth, and executes the neural network using the input to produce placement information for the dental appliance component with respect to the current dental anatomy of the dental restoration patient.