- 专利标题： POTENT AND SELECTIVE DEGRADERS OF ALK
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申请号： US17801709申请日： 2021-02-24
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公开(公告)号： US20230158157A1公开(公告)日： 2023-05-25
- 发明人: John M. Hatcher , Nathanael S. Gray , Baishan Jiang , Tinghu Zhang , Jianwei Che , Yang Gao , Lyn Howard Jones
- 申请人： DANA-FARBER CANCER INSTITUTE, INC.
- 申请人地址： US MA Boston
- 专利权人： DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人： DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US21/19424 2021.02.24
- 进入国家日期： 2022-08-23
- 主分类号： A61K47/55
- IPC分类号： A61K47/55
摘要：
Disclosed are bispecific compounds (degraders) that target ALK or ALK and FAK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bispecific compounds to treat diseases and disorders characterized or mediated by aberrant ALK or ALK and FAK activity.
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