公开(公告)号：US20240336643A1

公开(公告)日：2024-10-10

申请号：US18572945

申请日：2022-06-27

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： Baishan Jiang ,  John M. Hatcher ,  Lyn Howard Jones ,  Jianwei Che ,  Tinghu Zhang

IPC分类号： C07F9/6558 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/675 ,  A61K47/55 ,  A61P35/00 ,  C07D401/14

CPC分类号： C07F9/65583 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/675 ,  A61K47/55 ,  A61P35/00 ,  C07D401/14

摘要： Disclosed are bifunctional compounds (degraders) that target ALK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bifunctional compounds to treat diseases and disorders characterized or mediated by aberrant ALK activity.

公开(公告)号：US20240239785A1

公开(公告)日：2024-07-18

申请号：US18287972

申请日：2022-04-29

申请人： Neomorph, Inc. ,  Dana-Farber Cancer Institute, Inc.

发明人： Whitney L. Petrilli ,  Lyn Howard Jones ,  Hu Liu

IPC分类号： C07D417/14 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

CPC分类号： C07D417/14 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods for reducing IKZF2 and methods of treating cancer using the compounds of Formula (I).

公开(公告)号：US20230158157A1

公开(公告)日：2023-05-25

申请号：US17801709

申请日：2021-02-24

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： John M. Hatcher ,  Nathanael S. Gray ,  Baishan Jiang ,  Tinghu Zhang ,  Jianwei Che ,  Yang Gao ,  Lyn Howard Jones

IPC分类号： A61K47/55

CPC分类号： A61K47/55

摘要： Disclosed are bispecific compounds (degraders) that target ALK or ALK and FAK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bispecific compounds to treat diseases and disorders characterized or mediated by aberrant ALK or ALK and FAK activity.

公开(公告)号：US20240217970A1

公开(公告)日：2024-07-04

申请号：US18287347

申请日：2022-04-28

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： Tinghu Zhang ,  Lyn Howard Jones ,  Hu Liu ,  Jianwei Che

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  C07D401/14 ,  C07D405/14

摘要： Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that may bind to CRBN complex and cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders characterized or mediated by the presence of a protein, and hence would benefit from degradation of said protein.

公开(公告)号：US20230002397A1

公开(公告)日：2023-01-05

申请号：US17772384

申请日：2020-10-29

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： Nathanael S. Gray ,  Hu Liu ,  Tinghu Zhang ,  Lyn Howard Jones ,  Jianwei Che

IPC分类号： C07D487/10 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D413/14 ,  C07D417/14 ,  C07D491/107 ,  C07D487/08 ,  C07D419/14 ,  C07F9/6558 ,  C07D498/08

摘要： Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.