A digital buffer device with self-calibration includes a first buffer circuit, detection circuit, and calibration circuit. The first buffer circuit has a buffer input terminal for receiving an input signal and a buffer output terminal as output of the digital buffer device. The detection circuit includes at least one second buffer circuit for receiving at least one reference signal and generating at least one detection signal to indicate circuit characteristic variations of the at least one second buffer circuit. The at least one second buffer circuit is of a same type of buffer as the first buffer circuit. The calibration circuit has a calibration input terminal for receiving the input signal, and a calibration output terminal coupled to the buffer output terminal. The calibration circuit is for calibrating the first buffer circuit to generate an output signal according to the input signal and the at least one detection signal.