Invention Publication
- Patent Title: Synthesis of Vinylic Protected Alcohol Intermediates
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Application No.: US17918607Application Date: 2021-04-27
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Publication No.: US20230174496A1Publication Date: 2023-06-08
- Inventor: Austin G. SMITH , Liang HUANG
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- International Application: PCT/US21/29271 2021.04.27
- Date entered country: 2022-10-13
- Main IPC: C07D267/18
- IPC: C07D267/18 ; C07D513/04 ; C07D519/00
Abstract:
Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and R1 are described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
Information query
