公开(公告)号：US20170190739A1

公开(公告)日：2017-07-06

申请号：US15300209

申请日：2015-04-03

Applicant: AMGEN INC.

Inventor： Jeroen BEZEMER ,  Ying CHEN ,  Richard CROCKETT ,  Kevin CROSSLEY ,  Sheng CUI ,  Liang HUANG ,  Sian JONES ,  Asher LOWER ,  Krishnakumar RANGANATHAN

IPC: C07K7/06 ,  C07K1/107

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K1/1075

Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease—mineral and bone disorder (CKD-MBD).

公开(公告)号：US20230099078A1

公开(公告)日：2023-03-30

申请号：US17852263

申请日：2022-06-28

Applicant: AMGEN INC.

Inventor： Jeroen BEZEMER ,  Ying CHEN ,  Richard CROCKETT ,  Kevin CROSSLEY ,  Sheng CUI ,  Liang HUANG ,  Sian JONES ,  Asher LOWER ,  Krishnakumar RANGANATHAN

IPC: C07K7/06 ,  C07K1/107

Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

公开(公告)号：US20190352336A1

公开(公告)日：2019-11-21

申请号：US16532344

申请日：2019-08-05

Applicant: AMGEN INC.

Inventor： Jeroen BEZEMER ,  Ying CHEN ,  Richard CROCKETT ,  Kevin CROSSLEY ,  Sheng CUI ,  Liang HUANG ,  Sian JONES ,  Asher LOWER ,  Krishnakumar RANGANATHAN

IPC: C07K7/06 ,  C07K1/107

Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.

公开(公告)号：US20230174496A1

公开(公告)日：2023-06-08

申请号：US17918607

申请日：2021-04-27

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Liang HUANG

IPC: C07D267/18 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D267/18 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and R1 are described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.

公开(公告)号：US20230167130A1

公开(公告)日：2023-06-01

申请号：US17922619

申请日：2021-05-05

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Jason S. TEDROW ,  Gabrielle ST-PIERRE ,  Oliver Ralf THIEL ,  Liang HUANG ,  Philipp C. ROOSEN ,  John T. COLYER ,  Kyle D. BAUCOM ,  Ari ERICSON ,  Matthew G. BEAVER ,  Rahul P. SANGODKAR ,  Michael A. LOVETTE ,  Robert Ronald MILBURN ,  Alan H. CHERNEY ,  Sheng CUI

IPC: C07D513/10 ,  C07D267/16

CPC classification number: C07D513/10 ,  C07D267/16

Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.