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公开(公告)号：US20230099078A1
公开(公告)日：2023-03-30
申请号：US17852263
申请日：2022-06-28
申请人： AMGEN INC.
发明人： Jeroen BEZEMER , Ying CHEN , Richard CROCKETT , Kevin CROSSLEY , Sheng CUI , Liang HUANG , Sian JONES , Asher LOWER , Krishnakumar RANGANATHAN
摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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公开(公告)号：US20190352336A1
公开(公告)日：2019-11-21
申请号：US16532344
申请日：2019-08-05
申请人： AMGEN INC.
发明人： Jeroen BEZEMER , Ying CHEN , Richard CROCKETT , Kevin CROSSLEY , Sheng CUI , Liang HUANG , Sian JONES , Asher LOWER , Krishnakumar RANGANATHAN
摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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公开(公告)号：US20170190739A1
公开(公告)日：2017-07-06
申请号：US15300209
申请日：2015-04-03
申请人： AMGEN INC.
发明人： Jeroen BEZEMER , Ying CHEN , Richard CROCKETT , Kevin CROSSLEY , Sheng CUI , Liang HUANG , Sian JONES , Asher LOWER , Krishnakumar RANGANATHAN
CPC分类号： C07K7/06 , A61K38/00 , C07K1/1075
摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease—mineral and bone disorder (CKD-MBD).
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公开(公告)号：US20230174496A1
公开(公告)日：2023-06-08
申请号：US17918607
申请日：2021-04-27
申请人： AMGEN INC.
发明人： Austin G. SMITH , Liang HUANG
IPC分类号： C07D267/18 , C07D513/04 , C07D519/00
CPC分类号： C07D267/18 , C07D513/04 , C07D519/00
摘要： Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and R1 are described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
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公开(公告)号：US20230167130A1
公开(公告)日：2023-06-01
申请号：US17922619
申请日：2021-05-05
申请人： AMGEN INC.
发明人： Austin G. SMITH , Jason S. TEDROW , Gabrielle ST-PIERRE , Oliver Ralf THIEL , Liang HUANG , Philipp C. ROOSEN , John T. COLYER , Kyle D. BAUCOM , Ari ERICSON , Matthew G. BEAVER , Rahul P. SANGODKAR , Michael A. LOVETTE , Robert Ronald MILBURN , Alan H. CHERNEY , Sheng CUI
IPC分类号： C07D513/10 , C07D267/16
CPC分类号： C07D513/10 , C07D267/16
摘要： Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
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