Invention Publication
- Patent Title: OVERCOMING IMMUNE SUPPRESSION WITH TGF-B RESISTANT NK CELLS
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Application No.: US17922248Application Date: 2021-04-30
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Publication No.: US20230174940A1Publication Date: 2023-06-08
- Inventor: Dean Anthony LEE , Prashant TRIKHA , Aarohi THAKKAR , Jennifer FOLTZ , Meisam N. KARAROUDI , Jena E. MOSEMAN
- Applicant: Dean Anthony LEE , Prashant TRIKHA , Aarohi THAKKAR , Jennifer FOLTZ , Meisam N. KARAROUDI , Jena E. MOSEMAN , RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
- Applicant Address: US OH Canal Winchester
- Assignee: Dean Anthony LEE,Prashant TRIKHA,Aarohi THAKKAR,Jennifer FOLTZ,Meisam N. KARAROUDI,Jena E. MOSEMAN,RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
- Current Assignee: Dean Anthony LEE,Prashant TRIKHA,Aarohi THAKKAR,Jennifer FOLTZ,Meisam N. KARAROUDI,Jena E. MOSEMAN,RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
- Current Assignee Address: US OH Canal Winchester
- International Application: PCT/US21/30142 2021.04.30
- Date entered country: 2022-10-28
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K35/17 ; C07K14/495 ; C07K14/54 ; C07K14/705
Abstract:
Disclosed are engineered feeder cells comprising soluble or membrane bound TGF-b and methods of their use in the production of NK cells resistant to TGF-b and use of said generated TGF-b resistant NK cells to treat a cancer.
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