公开(公告)号：US20220323498A1

公开(公告)日：2022-10-13

申请号：US17641473

申请日：2020-09-10

Applicant: Dean Anthony LEE ,  Jena Edwards MOSEMAN ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

Inventor： Dean Anthony LEE ,  Jena Edwards MOSEMAN

IPC: A61K35/17 ,  G01N33/50 ,  G01N33/68 ,  A61K38/17

Abstract: Disclosed are compositions and methods for measuring the likelihood of recovery of a recently thawed immune cell. Methods include assaying the level of an ADAM-17-cleaved surface receptor expressed on the immune cells, wherein the level of the surface receptor directly correlates with the likelihood of immune cell recovery (i.e., the greater the increase of the expression level an ADAM-17-cleaved surface receptor relative to a control, the greater the likelihood of recovery). The method can be used to determine if immune cells have sufficient viability to be used in immunotherapy before use.

公开(公告)号：US20230174940A1

公开(公告)日：2023-06-08

申请号：US17922248

申请日：2021-04-30

Applicant: Dean Anthony LEE ,  Prashant TRIKHA ,  Aarohi THAKKAR ,  Jennifer FOLTZ ,  Meisam N. KARAROUDI ,  Jena E. MOSEMAN ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

Inventor： Dean Anthony LEE ,  Prashant TRIKHA ,  Aarohi THAKKAR ,  Jennifer FOLTZ ,  Meisam N. KARAROUDI ,  Jena E. MOSEMAN

IPC: C12N5/0783 ,  A61K35/17 ,  C07K14/495 ,  C07K14/54 ,  C07K14/705

CPC classification number: C12N5/0646 ,  A61K35/17 ,  C07K14/495 ,  C07K14/54 ,  C07K14/70578 ,  C12N2501/15 ,  C12N2501/2321 ,  C12N2501/599 ,  C12N2502/99

Abstract: Disclosed are engineered feeder cells comprising soluble or membrane bound TGF-b and methods of their use in the production of NK cells resistant to TGF-b and use of said generated TGF-b resistant NK cells to treat a cancer.