- 专利标题： CONDENSED SUBSTITUTED HYDROPYRROLES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
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申请号： US17920899申请日： 2021-04-23
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公开(公告)号： US20230183218A1公开(公告)日： 2023-06-15
- 发明人: Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Aaron M. Bender , Changho Han
- 申请人： Vanderbilt University
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 国际申请： PCT/US2021/028763 2021.04.23
- 进入国家日期： 2022-10-24
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07D403/12 ; C07D409/14 ; C07D417/14 ; C07D471/04 ; C07D403/14 ; C07D401/14 ; C07D487/04
摘要：
Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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