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1.发明公开公开(公告)号：US20230183219A1
公开(公告)日：2023-06-15
申请号：US17920904
申请日：2021-04-23
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Aaron M. Bender , Changho Han , Trever R. Carter , Matthew Spock
IPC分类号： C07D405/14 , C07D403/14 , C07D401/14 , C07D403/12 , C07D493/08 , C07D417/14
CPC分类号： C07D405/14 , C07D403/14 , C07D401/14 , C07D403/12 , C07D493/08 , C07D417/14 , C07B2200/05
摘要： Disclosed herein are substituted hexahydro-1//-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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2.发明公开公开(公告)号：US20230183218A1
公开(公告)日：2023-06-15
申请号：US17920899
申请日：2021-04-23
IPC分类号： C07D405/14 , C07D403/12 , C07D409/14 , C07D417/14 , C07D471/04 , C07D403/14 , C07D401/14 , C07D487/04
CPC分类号： C07D405/14 , C07D403/12 , C07D409/14 , C07D417/14 , C07D471/04 , C07D403/14 , C07D401/14 , C07D487/04
摘要： Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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公开(公告)号：US20240174655A1
公开(公告)日：2024-05-30
申请号：US18553408
申请日：2022-04-01
发明人： Aaron M. Bender , Matthew Spock , Changho Han , Trever R. Carter , P. Jeffrey Conn , Craig W. Lindsley
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Disclosed herein are (6-(2H-indazol-5-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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公开(公告)号：US20210188820A1
公开(公告)日：2021-06-24
申请号：US16757245
申请日：2018-10-20
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Julie L. Engers , Kayla J. Temple , Aaron M. Bender , Logan A. Baker
IPC分类号： C07D403/14 , C07D405/14 , C07D401/14 , C07D403/12 , C07D493/08 , C07D209/52 , C07D417/12 , C07D413/14 , C07D471/04
摘要： Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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公开(公告)号：US20240010640A1
公开(公告)日：2024-01-11
申请号：US18253094
申请日：2021-11-18
发明人： Aaron M. Bender , Matthew Spock , Melissa A. Korkmaz-Vaisys , Craig W. Lindsley , P. Jeffrey Conn
IPC分类号： C07D405/14 , C07D401/14
CPC分类号： C07D405/14 , C07D401/14
摘要： Disclosed herein are 6-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl-substituted pyridinones, pyrimidinones, and pyridazinones, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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公开(公告)号：US11851406B2
公开(公告)日：2023-12-26
申请号：US17251649
申请日：2019-06-13
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Julie L. Engers , Aaron M. Bender , Madeline Long
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.
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公开(公告)号：US20210355114A1
公开(公告)日：2021-11-18
申请号：US17287442
申请日：2019-10-24
IPC分类号： C07D405/14 , C07D405/10 , C07D413/14 , C07D413/10
摘要： Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.
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公开(公告)号：US11149022B2
公开(公告)日：2021-10-19
申请号：US16756430
申请日：2018-10-17
IPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D405/14
摘要： Disclosed herein are substituted 7-azaspiro[3.5]nonane compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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公开(公告)号：US20210261526A1
公开(公告)日：2021-08-26
申请号：US17251649
申请日：2019-06-13
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Julie L. Engers , Aaron M. Bender , Madeline Long
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.
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公开(公告)号：US20210188811A1
公开(公告)日：2021-06-24
申请号：US16756430
申请日：2018-10-17
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D409/14
摘要： Disclosed herein are substituted 7-azaspiro[3.5]nonane compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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